Diagnostic Accuracy of Combination of Multiparametric MRI PI-RADS Score v2.1 and Prostate-Specific Antigen Density for Prostate Cancer Detection

Introduction Prostate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. The Prostate Imaging-Reporting and Data System version 2.1 (PI-RADS v2.1) scoring system using multiparametric magnetic resonance imaging (mp-MRI) increases the accuracy for the assessment of clinically...

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Published in:Curēus (Palo Alto, CA) Vol. 17; no. 3; p. e80238
Main Authors: Shetty, Ashrita, Gadupati, Jahnavi, Bommineni, Bhagyalakshmi, Chikatla, Sowmya, Krishnamurthy, Umesh, D, Ramesh
Format: Journal Article
Language:English
Published: United States Springer Nature B.V 07.03.2025
Cureus
Subjects:
Accuracy
Antigens
Biopsy
Magnetic resonance imaging
Prostate cancer
Radiology
Ultrasonic imaging
Urology
prostate cancer
psa density
lesion volume
multiparameteric mri
pirads v2.1
ISSN:2168-8184, 2168-8184
Online Access:Get full text
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Summary:Introduction Prostate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. The Prostate Imaging-Reporting and Data System version 2.1 (PI-RADS v2.1) scoring system using multiparametric magnetic resonance imaging (mp-MRI) increases the accuracy for the assessment of clinically significant PCa. This study evaluates the diagnostic accuracy of a combination of PI-RADS v2.1 scores with prostate-specific antigen density (PSAD) for the detection of PCa, using biopsy outcomes as the gold standard, as well as the diagnostic accuracy of the combination of PI-RADS 3 lesion volume and PSAD. Methods This is single-center cross-sectional retrospective study including 54 subjects with serum PSA values > 4 ng/mL, who were referred for prostate mp-MRI. All patients underwent subsequent transrectal ultrasound (TRUS)-guided biopsy. Data collected includes PSA value, mp-MRI characteristics of the lesion, and histopathological findings. PI-RADS v2.1 score and PSAD were used to evaluate the diagnostic accuracy of this combination. Results In our study, the optimal PSAD cutoff was >0.18 with an area under the curve (AUC) of 0.897, indicating good diagnostic performance. The combination of PI-RADS v2.1 score ≥ 3 and PSAD ≥0.18 increased diagnostic accuracy, with a sensitivity of 96.97% and specificity of 71.43%. However, lesion volume was not a significant predictor of PCa. Conclusion In summary, our study demonstrates that the combination of PI-RADS score and PSAD yields higher diagnostic accuracy for the detection of PCa (p < 0.001) than using the PI-RADS score alone. We found an optimal PSAD cutoff of 0.18, which differs from the international consensus of 0.15. However, it cannot be used as a substitute for definitive pathological diagnosis but can be used in combination for better risk stratification, counselling, and management of patients with elevated PSA levels. Combining PI-RADS 3 lesion volume and PSAD did not have statistically significant results in our study.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.80238