PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia

The transcriptional mediator LIM domain only 2 (LMO2) forms a large multi-protein complex together with TAL1/LYL1, HEB/E2A, LDB1 and GATA. This complex regulates transcription from the onset of hematopoietic development and during differentiation. Chromosomal rearrangements involving LMO2 and TAL1 a...

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Bibliographic Details
Published in:	Haematologica (Roma) Vol. 999; no. 1
Main Authors:	Stanulović, Vesna S., Binhassan, Sarah, Jaber, Budoor A., Alazmi, Shimaa, Saleman, Fatma M.B., Potluri, Sandeep, Pratt, Guy, Ludwig, Christian, Ward, Douglas G., Hoogenkamp, Maarten
Format:	Journal Article
Language:	English
Published:	Italy Ferrata Storti Foundation 10.07.2025
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
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Summary:	The transcriptional mediator LIM domain only 2 (LMO2) forms a large multi-protein complex together with TAL1/LYL1, HEB/E2A, LDB1 and GATA. This complex regulates transcription from the onset of hematopoietic development and during differentiation. Chromosomal rearrangements involving LMO2 and TAL1 are causative for T-cell lymphoblastic leukemia (TALL). We have identified Plant Homeodomain (PHD)-like Finger 6 (PHF6) as a new LMO2 interacting factor. Somatic mutations in PHF6 have been found to occur in several types of leukemia. We show that PHF6 interacts with LMO2 as a part of the TAL1, GATA2, LDB1 complex in T-ALL and binds to the DNA. These findings show that PHF6 associates with the TAL1/LMO2/LDB1/GATA2 complex and regulates genes that have a major role in blood development, such as SPI1 (PU.1).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0390-6078 1592-8721 1592-8721
DOI:	10.3324/haematol.2024.287124