CRISPR-Cas9 Mediated AGO2 Knockout inhibits tumorigenesis in human colorectal cancer cells

AGO2 plays a vital role in small RNA-guided gene silencing, which has been implied in the tumorigenesis of different types of tumors. Fundamentally, increased expression of AGO2 protein is associated with cancer progression and metastasis. This study aims to investigate the molecular mechanism by wh...

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Veröffentlicht in:	Cellular and molecular biology (Noisy-le-Grand, France) Jg. 70; H. 7; S. 174
Hauptverfasser:	Zhu, Yizhi, Wang, Gengfang, Xu, Haoran, Guo, Yuan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	France 28.07.2024
Schlagworte:	Argonaute Proteins - genetics Argonaute Proteins - metabolism Carcinogenesis - genetics Carcinogenesis - pathology Cell Movement - genetics Cell Proliferation - genetics Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology CRISPR-Cas Systems - genetics Gene Expression Regulation, Neoplastic Gene Knockout Techniques HCT116 Cells Humans MicroRNAs - genetics MicroRNAs - metabolism
ISSN:	1165-158X, 1165-158X
Online-Zugang:	Weitere Angaben
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