Developing RNAi pesticides in the post genomic era: A review
RNA interference (RNAi) has emerged as a promising platform for next-generation pesticides, offering high target specificity and environmental safety. In the post-genomic era, rapid advances in insect genomics, delivery systems, and bioinformatics have significantly accelerated the development of RN...
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| Veröffentlicht in: | Advanced Agrochem |
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| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Elsevier B.V
01.07.2025
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| Schlagworte: | |
| ISSN: | 2773-2371, 2773-2371 |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | RNA interference (RNAi) has emerged as a promising platform for next-generation pesticides, offering high target specificity and environmental safety. In the post-genomic era, rapid advances in insect genomics, delivery systems, and bioinformatics have significantly accelerated the development of RNAi-based pest control strategies. This review summarizes current progress in RNAi mechanism elucidation, target gene selection, and delivery approaches including host-induced gene silencing (HIGS), spray-induced gene silencing (SIGS), and virus-induced gene silencing (VIGS). Key challenges—such as interspecies variability in RNAi efficiency, dsRNA degradation, and off-target effects—are discussed in detail. Machine learning (ML) and genome-wide screening play a critical role in optimizing siRNA design and reducing ecological risks. Commercial products such as Ledprona and MON87411 maize exemplify the practical potential of RNAi-based pesticides. Future success will depend on integrating comparative genomics, ML-based off-target prediction, and ecological risk assessment frameworks to ensure safety and sustainability in applications. |
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| ISSN: | 2773-2371 2773-2371 |
| DOI: | 10.1016/j.aac.2025.07.002 |