41. Epileptiform activity and epileptic seizures in brain injured patients with prolonged disorders of consciousness

Brain injured patients might show “late” seizures beyond one week from injury. In the present observational study we analyzed occurrence of epileptiform activity (EA) and late Epileptic Seizures (ES) during neurorehabilitation stay in 130 traumatic, vascular and anoxic DOC patients (77 males, mean a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clinical neurophysiology Ročník 127; číslo 12; s. e333
Hlavní autoři: Estraneo, A., Pascarella, A., Loreto, V.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Elsevier Ireland Ltd 01.12.2016
Témata:
Neurology
ISSN:1388-2457, 1872-8952
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Brain injured patients might show “late” seizures beyond one week from injury. In the present observational study we analyzed occurrence of epileptiform activity (EA) and late Epileptic Seizures (ES) during neurorehabilitation stay in 130 traumatic, vascular and anoxic DOC patients (77 males, mean age: 55.8±17.33), with a clinical diagnosis of vegetative state (n=97) or minimally conscious state (n=33). We also investigated impact of EA and ES on patients’ long-term (30months post-onset) clinical outcome. EA resulted to be present in 61/130 (46.9%) DOC patients and ES occurred in 35/130 (26.9%) DOC without significant differences in the clinical diagnosis or etiology. Among patients with EA, only 26/61 (42.6%) develop clinically evident ES. Mortality at 30months did not significantly differ in DOC patients with or without ES and in DOC patients with of without EA (37.5% vs. 35.8%; p=.86). The proportion of “recovered” patients was higher in patients without ES than in patients with ES (70.5% vs. 48.0%; p=.064), whereas the proportion of recovered patients did not differ between patients without or with EA (64.7% vs. 60.0%; chi-square<1). Presence of ES, but not of EA, significantly impact on recovery of consciousness and level of responsiveness at long-term outcome.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2016.10.053