Features of Erythropoiesis in Long-Tailed Ground Squirrels Urocitellus undulatus at Arousal from Hibernation

The present study constitutes a continuation of earlier research on erythropoiesis in hibernating long-tailed ground squirrels ( Urocitellus undulatus ), which revealed morpho functional differences between the bone marrow (BM) of the humerus and femur of animals. It has been suggested that the obse...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology Vol. 61; no. 5; pp. 1532 - 1543
Main Authors: Lizorkina, K., Tarahovsky, Yu. S., Aksenova, G. E., Pyatina, K., Afanasyev, V. N., Zakharova, N. M.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01.10.2025
Springer Nature B.V
Subjects:
Animal Physiology
Anticoagulants
Arousal
Biochemistry
Biomedical and Life Sciences
Body temperature
Bone marrow
Cell cycle
Erythropoiesis
Evolutionary Biology
Experimental Papers
Femur
Flow cytometry
Hibernation
Humerus
Life Sciences
Metabolism
Metabolites
Rodents
Software
Veterinary medicine
Austria
United States > US
China
Germany
Russia
ground squirrel
erythropoiesis
hibernation
bone marrow
arousal
ISSN:0022-0930, 1608-3202
Online Access:Get full text
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Summary:The present study constitutes a continuation of earlier research on erythropoiesis in hibernating long-tailed ground squirrels ( Urocitellus undulatus ), which revealed morpho functional differences between the bone marrow (BM) of the humerus and femur of animals. It has been suggested that the observed characteristics may be indicative of the inherited adaptation of hibernating animals to significant internal temperature gradients that occur during their periodic awakenings. In order to verify this assumption а comprehensive investigation encompassing the analysis of flow cytometry and histological features of the humeral and femoral BM, complemented by a series of hematological and biochemical blood tests conducted at various stages of the life cycle of nuclear cells, was undertaken. The findings of this investigation revealed that during the arousal, the femoral BM exerts the most significant influence on the formation of a proliferative pool of cells implicated in the process of erythropoiesis. Concurrently, the humeral BM assumes a pivotal role in the maintenance of a polypotent cellular composition. The obtained data have expanded fundamental knowledge of the processes responsible for stable erythropoiesis in hibernating animals under critical conditions of transition from a torpid to a euthermic state.
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ISSN:0022-0930
1608-3202
DOI:10.1134/S1234567825600361