Pegcetacoplan compared with supportive care for 26 weeks for participants with paroxysmal nocturnal hemoglobinuria: a plain language summary

In the PRINCE study, adults with paroxysmal nocturnal hemoglobinuria (PNH) who had not recently taken a C5 complement inhibitor medicine received pegcetacoplan or supportive care. Pegcetacoplan reduced hemolysis better than supportive care and was well tolerated.

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Published in:Future Rare Diseases Vol. 4; no. 1
Main Authors: Ming Wong, Raymond Siu, Navarro-Cabrera, Juan Ramon, Comia, Narcisa Sonia, Goh, Yeow Tee, Idrobo, Henry, Kongkabpan, Daolada, Gómez-Almaguer, David, Al-Adhami, Mohammed, Ajayi, Temitayo, Alvarenga, Paulo, Savage, Jessica, Deschatelets, Pascal, Francois, Cedric, Grossi, Federico, Dumagay, Teresita
Format: Journal Article
Language:English
Published: Future Medicine Ltd 31.12.2024
Subjects:
anemia
lay summary
paroxysmal nocturnal hemoglobinuria
pegcetacoplan
plain language summary
ISSN:2399-5262, 2399-5270, 2399-5270
Online Access:Get full text
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Abstract In the PRINCE study, adults with paroxysmal nocturnal hemoglobinuria (PNH) who had not recently taken a C5 complement inhibitor medicine received pegcetacoplan or supportive care. Pegcetacoplan reduced hemolysis better than supportive care and was well tolerated.
AbstractList In the PRINCE study, adults with paroxysmal nocturnal hemoglobinuria (PNH) who had not recently taken a C5 complement inhibitor medicine received pegcetacoplan or supportive care. Pegcetacoplan reduced hemolysis better than supportive care and was well tolerated.
Author Goh, Yeow Tee
Dumagay, Teresita
Idrobo, Henry
Alvarenga, Paulo
Deschatelets, Pascal
Ajayi, Temitayo
Grossi, Federico
Kongkabpan, Daolada
Ming Wong, Raymond Siu
Comia, Narcisa Sonia
Savage, Jessica
Francois, Cedric
Navarro-Cabrera, Juan Ramon
Al-Adhami, Mohammed
Gómez-Almaguer, David
AuthorAffiliation 9Department of Cellular Therapeutics, Makati Medical Centre, Makati City, Philippines
5Department of Haematology, Julian Coronel Medical Center, Cali, Colombia
6Department of Medicine, Songklanagarind Hospital, Songkhla, Thailand
4Department of Haematology, Singapore General Hospital, Singapore
1Sir YK Pao Centre for Cancer & Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
7Department of Haematology, University Hospital Dr. José Eleuterio González, Monterrey, Mexico
3Research Center, Mary Mediatrix Medical Center, Lipa, Philippines
8Apellis Pharmaceuticals, Inc., Waltham, MA, USA
2Department of Hematology, Edgardo Rebagliati Hospital, Lima, Peru
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Snippet In the PRINCE study, adults with paroxysmal nocturnal hemoglobinuria (PNH) who had not recently taken a C5 complement inhibitor medicine received pegcetacoplan...
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SubjectTerms anemia
lay summary
paroxysmal nocturnal hemoglobinuria
pegcetacoplan
plain language summary
Title Pegcetacoplan compared with supportive care for 26 weeks for participants with paroxysmal nocturnal hemoglobinuria: a plain language summary
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