Reduction in hepatic endothelin-1 clearance in cirrhosis

Circulating endothelin-1 (ET-1) levels are increased in cirrhosis. The liver is an important site for circulating ET-1 clearance through the ET(B) receptor. We evaluated ET-1 kinetics in cirrhosis to determine if a reduced liver clearance contributes to this process. Cirrhosis was induced by carbon...

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Bibliographic Details

Published in:	Clinical science (1979) Vol. 105; no. 2; p. 227
Main Authors:	Tran Duc, Anh Thu, Schwab, Andreas J, Simard, André, Villeneuve, Louis, Dupuis, Jocelyn
Format:	Journal Article
Language:	English
Published:	England 01.08.2003
Subjects:	Animals Blood Pressure Carbon Tetrachloride Endothelin-1 - blood Endothelin-1 - metabolism Liver - metabolism Liver Cirrhosis, Experimental - blood Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Male Portal Vein - physiopathology Rats Rats, Sprague-Dawley Receptor, Endothelin B Receptors, Endothelin - metabolism
ISSN:	0143-5221
Online Access:	Get more information
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