91726 Screening for Obesity related renal damage in adolescent women - Body Surface area matters
ABSTRACT IMPACT: This change will improve primary care physicians and pediatrics ability to identify, intervene and prevent obesity related renal damage in the vulnerable population of young adults OBJECTIVES/GOALS: Obesity related glomerulopathy has a reversible stage manifested as hyperfiltration....
Gespeichert in:
| Veröffentlicht in: | Journal of clinical and translational science Jg. 5; H. s1; S. 25 - 26 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Cambridge, UK
Cambridge University Press
01.03.2021
|
| Schlagworte: | |
| ISSN: | 2059-8661, 2059-8661 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | ABSTRACT IMPACT: This change will improve primary care physicians and pediatrics ability to identify, intervene and prevent obesity related renal damage in the vulnerable population of young adults OBJECTIVES/GOALS: Obesity related glomerulopathy has a reversible stage manifested as hyperfiltration. Early intervention depends on the ability to identify hyperfiltration. Hyperfiltration prevalence is underestimated using the currently recommended formula We investigated whether calculating BSA-adjusted GFR will more readily identify hyperfiltration. METHODS/STUDY POPULATION: We extracted data from a large urban, multi-institutional Electronic Health Records (EHR) clinical data research network to construct an EHR data base of 60,549 women and girls ages 12-21 years from the New York metropolitan area. EGFR was calculated in two ways, 1) according to age appropriate formula, and 2) according to age appropriate formula and adjusted to body surface area (BSA). BMI-for-age values were classified according to the World Health Organization schema and grouped according to the CDC definitions. BSA was calculated according to the Du-Bois formula. Hyperfiltration was defined by a threshold of 135ml/min. The Bland Altman method assessed the agreement between formulas across the different BMI groups. RESULTS/ANTICIPATED RESULTS: Serum creatinine values were similar across different BMI groups. Comparing eGFR values, hyperfiltration rates were similar across BMI groups, ranging between 4%-6.6%. BSA-adjusted GFR was different across BMI groups: hyperfiltration rates were 0.81% for the underweight group, 2.56% for the normal weight, 12.18% for the overweight and 39% in the obese group. This trend of hyperfiltration paralleled the the rise in urine creatinine across BMI groups. DISCUSSION/SIGNIFICANCE OF FINDINGS: BSA-adjusted GFR more sensitively detects hyperfiltration due to obesity than does eGFR. Calculating BSA-adjusted GFR will improve primary care and pediatric physicians’ ability to identify, intervene and prevent early ORG. Changes in body composition may account for the increasing discordance between BSA-adjusted and eGFR as BMI rises. |
|---|---|
| AbstractList | ABSTRACT IMPACT: This change will improve primary care physicians and pediatrics ability to identify, intervene and prevent obesity related renal damage in the vulnerable population of young adults OBJECTIVES/GOALS: Obesity related glomerulopathy has a reversible stage manifested as hyperfiltration. Early intervention depends on the ability to identify hyperfiltration. Hyperfiltration prevalence is underestimated using the currently recommended formula We investigated whether calculating BSA-adjusted GFR will more readily identify hyperfiltration. METHODS/STUDY POPULATION: We extracted data from a large urban, multi-institutional Electronic Health Records (EHR) clinical data research network to construct an EHR data base of 60,549 women and girls ages 12-21 years from the New York metropolitan area. EGFR was calculated in two ways, 1) according to age appropriate formula, and 2) according to age appropriate formula and adjusted to body surface area (BSA). BMI-for-age values were classified according to the World Health Organization schema and grouped according to the CDC definitions. BSA was calculated according to the Du-Bois formula. Hyperfiltration was defined by a threshold of 135ml/min. The Bland Altman method assessed the agreement between formulas across the different BMI groups. RESULTS/ANTICIPATED RESULTS: Serum creatinine values were similar across different BMI groups. Comparing eGFR values, hyperfiltration rates were similar across BMI groups, ranging between 4%-6.6%. BSA-adjusted GFR was different across BMI groups: hyperfiltration rates were 0.81% for the underweight group, 2.56% for the normal weight, 12.18% for the overweight and 39% in the obese group. This trend of hyperfiltration paralleled the the rise in urine creatinine across BMI groups. DISCUSSION/SIGNIFICANCE OF FINDINGS: BSA-adjusted GFR more sensitively detects hyperfiltration due to obesity than does eGFR. Calculating BSA-adjusted GFR will improve primary care and pediatric physicians’ ability to identify, intervene and prevent early ORG. Changes in body composition may account for the increasing discordance between BSA-adjusted and eGFR as BMI rises. |
| Author | Bentur, O.S. Renert-Yuval, Y. Vasquez, K. Bielopolski, D. Vaughan, R.D. Kost, R.G. Singh, N. MacArthur, R. Tobin, J.N. Moftah, D.S. |
| AuthorAffiliation | 2 Clinical Directors Network (CDN) , New York , NY 1 The Rockefeller University Center for Clinical and Translational Science , New York , NY |
| AuthorAffiliation_xml | – name: 2 Clinical Directors Network (CDN) , New York , NY – name: 1 The Rockefeller University Center for Clinical and Translational Science , New York , NY |
| Author_xml | – sequence: 1 givenname: D. surname: Bielopolski fullname: Bielopolski, D. – sequence: 2 givenname: N. surname: Singh fullname: Singh, N. – sequence: 3 givenname: O.S. surname: Bentur fullname: Bentur, O.S. – sequence: 4 givenname: Y. surname: Renert-Yuval fullname: Renert-Yuval, Y. – sequence: 5 givenname: R. surname: MacArthur fullname: MacArthur, R. – sequence: 6 givenname: K. surname: Vasquez fullname: Vasquez, K. – sequence: 7 givenname: D.S. surname: Moftah fullname: Moftah, D.S. – sequence: 8 givenname: R.D. surname: Vaughan fullname: Vaughan, R.D. – sequence: 9 givenname: R.G. surname: Kost fullname: Kost, R.G. – sequence: 10 givenname: J.N. surname: Tobin fullname: Tobin, J.N. |
| BookMark | eNpVkdtqFTEUhoNUsNbe-QB5AGebw-R0I2jxUCj0or2PycrKdspMUpKpst_e2W4Re_Uv1mJ98PO9JmelFiTkLWc7zrh5D2vfCSb4bjTsBTkXTLnBas3P_ptfkcveHxhj3AqtpTwn3x03QtM7aIhlKnuaa6O3Efu0HmjDOayYtixhpiksYY90KjSkOmMHLCv9VRcsdKCfajrQu6eWAyANDQNdwrpi62_Iyxzmjpd_84Lcf_l8f_VtuLn9en318WYA7jQbJOSYAE0Gl0cAq7NN0kQnnRPCQN4qyNFYxaxTEZONIoJVeoTEFGSUF-T6hE01PPjHNi2hHXwNk_-zqG3vQ1snmNEnVKh0DjKDGCVT1kQL6DBFzjkmvbE-nFiPT3HBdOzZwvwM-vxSph9-X396a4UxRm2AdycAtNp7w_zvlzN_lOU3Wf4oy2-y5G_fYosc |
| ContentType | Journal Article |
| Copyright | The Association for Clinical and Translational Science 2021 2021 The Association for Clinical and Translational Science |
| Copyright_xml | – notice: The Association for Clinical and Translational Science 2021 2021 The Association for Clinical and Translational Science |
| DBID | AAYXX CITATION 5PM DOA |
| DOI | 10.1017/cts.2021.470 |
| DatabaseName | CrossRef PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2059-8661 |
| EndPage | 26 |
| ExternalDocumentID | oai_doaj_org_article_de5e56fa3fc2430587b8ce9edb111ed6 PMC8827775 10_1017_cts_2021_470 |
| GroupedDBID | 09C 09E 0R~ 8FE 8FH AABES AABWE AAGFV AAKTX AASVR AAYXX ABGDZ ABQTM ABROB ABVZP ABXHF ACAJB ACBEK ACDLN ACGFS ACUIJ ADAZD ADBBV ADDNB ADKIL ADOVH ADVJH AEBAK AEHGV AEMTJ AEYHU AFFHD AFKQG AFKRA AFLVW AFZFC AGABE AGJUD AHIPN AHQXX AHRGI AIGNW AIHIV AIOIP AJCYY AKMAY ALMA_UNASSIGNED_HOLDINGS ANPSP AQJOH ARCSS AUXHV AZGZS BBLKV BBNVY BCNDV BENPR BHPHI BLZWO BMAJL BRIRG CBIIA CCPQU CCQAD CFAFE CITATION CJCSC DOHLZ GROUPED_DOAJ HCIFZ HYE IKXGN IOEEP IPYYG JHPGK JKPOH JQKCU JVRFK KCGVB KFECR LK8 M7P M~E NIKVX OK1 PHGZM PHGZT PQGLB RCA ROL RPM S6U SAAAG T9M WFFJZ ZYDXJ 5PM |
| ID | FETCH-LOGICAL-c1960-3cfbdce7fc9f4cc86f8d37b9399227cf205347850895bed8b2bc8564cd05cfe3 |
| IEDL.DBID | DOA |
| ISSN | 2059-8661 |
| IngestDate | Tue Oct 14 18:33:57 EDT 2025 Tue Nov 04 01:58:00 EST 2025 Sat Nov 29 01:40:27 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | s1 |
| Language | English |
| License | http://creativecommons.org/licenses/by/4.0 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c1960-3cfbdce7fc9f4cc86f8d37b9399227cf205347850895bed8b2bc8564cd05cfe3 |
| OpenAccessLink | https://doaj.org/article/de5e56fa3fc2430587b8ce9edb111ed6 |
| PageCount | 2 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_de5e56fa3fc2430587b8ce9edb111ed6 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8827775 crossref_primary_10_1017_cts_2021_470 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-03-01 |
| PublicationDateYYYYMMDD | 2021-03-01 |
| PublicationDate_xml | – month: 03 year: 2021 text: 2021-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Cambridge, UK |
| PublicationPlace_xml | – name: Cambridge, UK |
| PublicationTitle | Journal of clinical and translational science |
| PublicationYear | 2021 |
| Publisher | Cambridge University Press |
| Publisher_xml | – name: Cambridge University Press |
| SSID | ssj0001826633 |
| Score | 2.1360097 |
| Snippet | ABSTRACT IMPACT: This change will improve primary care physicians and pediatrics ability to identify, intervene and prevent obesity related renal damage in the... |
| SourceID | doaj pubmedcentral crossref |
| SourceType | Open Website Open Access Repository Index Database |
| StartPage | 25 |
| SubjectTerms | Clinical Epidemiology Data Science/Biostatistics/Informatics |
| Title | 91726 Screening for Obesity related renal damage in adolescent women - Body Surface area matters |
| URI | https://pubmed.ncbi.nlm.nih.gov/PMC8827775 https://doaj.org/article/de5e56fa3fc2430587b8ce9edb111ed6 |
| Volume | 5 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAEN databaseName: Cambridge University Press Wholly Gold Open Access Journals customDbUrl: eissn: 2059-8661 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001826633 issn: 2059-8661 databaseCode: IKXGN dateStart: 20170201 isFulltext: true titleUrlDefault: http://journals.cambridge.org/action/login providerName: Cambridge University Press – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2059-8661 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001826633 issn: 2059-8661 databaseCode: DOA dateStart: 20170101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2059-8661 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001826633 issn: 2059-8661 databaseCode: M~E dateStart: 20160101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2059-8661 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001826633 issn: 2059-8661 databaseCode: M7P dateStart: 20170201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2059-8661 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001826633 issn: 2059-8661 databaseCode: BENPR dateStart: 20170201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ07T8MwEMctVDGwIBAgykseYAzkbXukqBUDVEitULcQn23RoSkqLRILn507J0DKwsKSSHk6d7HvLvrnZ8bOtSRtuYIAhNBBqmwZyKiMAieIJ55ExnnizeOdGA7lZKIeWlN9kSasxgPXhrsyNrNZ7srEQUx4Kim0BKus0dhLrfGw7VCoVjHlv65g1pwnSaN0J0Y0LAnOHUeXKc1L3IpBHtX_WxLZijGDHbbdJIf8um7ULtuw1R57wlInzvkISCGDgYZjmskbnj_3v6JYg2s60ZQzHB74tOI_oCbuGQs84L25eeej1cKVYHmJuSKf1WzNfTYe9Mc3t0EzL0IA2F9w2ASnsaHCgXIpgMydNInQyjNmBbgYO1YqJKZeKtPWSB1rkFmeggkzcDY5YJ1qXtlDxsOSiHuElMMobZ0lnF1okhDyRKQ6dV128WWo4qWmXxS1LEwUaNCCDFqgQbusR1b8PoaY1X4DerJoPFn85ckuE2s-WLva-p5q-uxJ2FgeCCGyo_-4_THbosep9WUnrLNcrOwp24S35fR1ceZfL1zef_Q_Ac7W2Vk |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=91726+Screening+for+Obesity+related+renal+damage+in+adolescent+women+-+Body+Surface+area+matters&rft.jtitle=Journal+of+clinical+and+translational+science&rft.au=Bielopolski%2C+D.&rft.au=Singh%2C+N.&rft.au=Bentur%2C+O.S.&rft.au=Renert-Yuval%2C+Y.&rft.date=2021-03-01&rft.pub=Cambridge+University+Press&rft.eissn=2059-8661&rft.volume=5&rft.issue=Suppl+1&rft.spage=25&rft.epage=26&rft_id=info:doi/10.1017%2Fcts.2021.470&rft.externalDocID=PMC8827775 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2059-8661&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2059-8661&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2059-8661&client=summon |