Effects of complement C3/C3b inhibition on control of malignant effusions and neutrophil phenotypes in patients with recurrent epithelial ovarian cancer: Interim analysis of a phase 2 clinical trial

Malignant effusions (ME) can promote metastatic seeding and are challenging to manage. Using ME from patients with epithelial ovarian cancer (OC) and other solid tumors as authentic components of the tumor microenvironment (TME), we observed that ME reprogram neutrophils to acquire complement-depend...

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Veröffentlicht in:	Immunobiology (1979) Jg. 230; H. 4; S. 152995
Hauptverfasser:	Zsiros, Emese, Nazmul Khan, A.N.M., Giridharan, Thejaswini, Suzuki, Sora, DeJohn, Celia, Hess, Suzanne, Mager, Katherine, Werner, Sarah, McLean, Karen, Gaulin, Nicole, Frederick, Peter, Puzanov, Igor, Kolev, Martin, Deschatelets, Pascal, Segal, Brahm
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Elsevier GmbH 01.07.2025
ISSN:	0171-2985
Online-Zugang:	Volltext
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