Computer modelling and simulation of a novel printing head for complex tissue engineering constructs

In tissue engineering, three-dimensional functional scaffolds with tailored biological properties are needed to be able to mimic the hierarchical structure of biological tissues. Recent developments in additive biomanufacturing allow to extrude multiple materials enabling the fabrication of more sop...

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Vydáno v:MATEC web of conferences Ročník 318; s. 1045
Hlavní autor: Ates, Gokhan
Médium: Journal Article Konferenční příspěvek
Jazyk:angličtina
Vydáno: Les Ulis EDP Sciences 2020
Témata:
Biological properties
Biomedical materials
Biomimetic materials
Biotechnology
Computational fluid dynamics
Computer simulation
Construction engineering
Construction materials
Extrusion
Fluid flow
Functionally gradient materials
Mathematical models
Nozzles
Printers (data processing)
Printing
Reynolds number
Structural hierarchy
Tissue engineering
ISSN:2261-236X, 2274-7214, 2261-236X
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Shrnutí:In tissue engineering, three-dimensional functional scaffolds with tailored biological properties are needed to be able to mimic the hierarchical structure of biological tissues. Recent developments in additive biomanufacturing allow to extrude multiple materials enabling the fabrication of more sophisticated tissue constructs. These multi-material biomanufacturing systems comprise multiple printing heads through which individual materials are sequentially printed. Nevertheless, as more printing heads are added the fabrication process significantly decreases, since it requires mechanical switching among the physically separated printheads to enable printing multiple materials. In addition, this approach is not able to create biomimetic tissue constructs with property gradients. To address these limitations, this paper presents a novel static mixing extrusion printing head to enable the fabrication of multi-material, functionally graded structures using a single nozzle. Computational fluid dynamics (CFD) was used to numerically analyze the influence of Reynolds number on the flow pattern of biomaterials and mixing efficiency considering different miscible materials.
Bibliografie:ObjectType-Conference Proceeding-1
SourceType-Conference Papers & Proceedings-1
content type line 21
ISSN:2261-236X
2274-7214
2261-236X
DOI:10.1051/matecconf/202031801045