DIPG-74. RE-IRRADIATION OF DIPG: DATA FROM THE INTERNATIONAL DIPG REGISTRY

Abstract PURPOSE To review data from DIPG Registry patients recorded to have received a second course of radiation therapy (rRT). METHODS The International DIPG Registry was searched for patients with DIPG who were treated with a known dose of rRT. Doses of rRT, timing from initial diagnosis and pri...

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Vydané v:	Neuro-oncology (Charlottesville, Va.) Ročník 22; číslo Supplement_3; s. iii301 - iii302
Hlavní autori:	Lafay-Cousin, Lucie, Lane, Adam, Schafer, Austin, Saab, Raya, Cheng, Sylvia, Bandopadhayay, Pratiti, Zaghloul, Mohamed, El-Ayadi, Motasem, Dorris, Kathleen, Packer, Roger, Kilburn, Lindsey, Minturn, Jane, Dodgshun, Andrew, Parkin, Sara, Lombardi, Mercedes Garcia, Cohen, Kenneth, Gass, David, Goldman, Stewart, Sandler, Eric, Warren, Katherine, Greiner, Robert, Gottardo, Nicholas, Dholaria, Hetal, Hassall, Tim, Coven, Scott, Hansford, Jordan, Samson, Yvan, Leary, Sarah, Bartels, Ute, Bouffet, Eric, Ma, Jie, Tinkle, Christopher, Monje-Deisseroth, Michelle, Fisher, Paul, Tsui, Karen, Ziegler, David, Chintagumpala, Murali, Gururangan, Sridharan, Wagner, Lars, Koschmann, Carl, DeWire-Schottmiller, Mariko, Leach, James, Jones, Blaise, Fuller, Christine, Drissi, Rachid, Chaney, Brooklyn, Black, Katie, Fouladi, Maryam, Strother, Douglas
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	US Oxford University Press
ISSN:	1522-8517, 1523-5866
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Abstract	Abstract PURPOSE To review data from DIPG Registry patients recorded to have received a second course of radiation therapy (rRT). METHODS The International DIPG Registry was searched for patients with DIPG who were treated with a known dose of rRT. Doses of rRT, timing from initial diagnosis and primary radiation therapy (pRT), radiographic response to rRT and survival from diagnosis (OS) were evaluated. RESULTS Sixty (11.2%) of 535 Registry patients underwent rRT; dose was provided for 44 patients. Median (range) data from those 44 revealed that rRT was given at 12 (2–65) months from initial diagnosis of DIPG and at 9.6 (1–61) months from completion of pRT at a dose of 26.7 (1.8–74) Gy. After completion of rRT, MRI showed response, progression, stable disease or was not available in 19, 8, 3 and 14 patients, respectively. Median PFS and OS were 11 and 18.1 months, respectively. 475 Registry patients did not undergo rRT; their ages, duration of symptoms, and primary treatment with or without chemotherapy were not significantly different from the rRT cohort. Median PFS and OS for the non-rRT patients were 6.9 and 10 months, respectively. rRT patients were more likely to have had radiographic evidence of tumor necrosis at diagnosis than non-rRT patients. CONCLUSIONS Administration of rRT to patients with DIPG has been inconsistent with respect to timing and dose. Toxicity, response and quality of life data are incomplete, but survival appears to be lengthened with rRT. Prospective clinical trials will elucidate benefits and risks of rRT.
AbstractList	Abstract PURPOSE To review data from DIPG Registry patients recorded to have received a second course of radiation therapy (rRT). METHODS The International DIPG Registry was searched for patients with DIPG who were treated with a known dose of rRT. Doses of rRT, timing from initial diagnosis and primary radiation therapy (pRT), radiographic response to rRT and survival from diagnosis (OS) were evaluated. RESULTS Sixty (11.2%) of 535 Registry patients underwent rRT; dose was provided for 44 patients. Median (range) data from those 44 revealed that rRT was given at 12 (2–65) months from initial diagnosis of DIPG and at 9.6 (1–61) months from completion of pRT at a dose of 26.7 (1.8–74) Gy. After completion of rRT, MRI showed response, progression, stable disease or was not available in 19, 8, 3 and 14 patients, respectively. Median PFS and OS were 11 and 18.1 months, respectively. 475 Registry patients did not undergo rRT; their ages, duration of symptoms, and primary treatment with or without chemotherapy were not significantly different from the rRT cohort. Median PFS and OS for the non-rRT patients were 6.9 and 10 months, respectively. rRT patients were more likely to have had radiographic evidence of tumor necrosis at diagnosis than non-rRT patients. CONCLUSIONS Administration of rRT to patients with DIPG has been inconsistent with respect to timing and dose. Toxicity, response and quality of life data are incomplete, but survival appears to be lengthened with rRT. Prospective clinical trials will elucidate benefits and risks of rRT.
Author	Cohen, Kenneth Chintagumpala, Murali Samson, Yvan Schafer, Austin Tinkle, Christopher Black, Katie Bouffet, Eric Lombardi, Mercedes Garcia Dholaria, Hetal Fouladi, Maryam Dodgshun, Andrew Cheng, Sylvia Kilburn, Lindsey Gururangan, Sridharan El-Ayadi, Motasem Zaghloul, Mohamed Bartels, Ute Wagner, Lars Sandler, Eric Warren, Katherine Hassall, Tim Monje-Deisseroth, Michelle Bandopadhayay, Pratiti Ziegler, David Tsui, Karen DeWire-Schottmiller, Mariko Parkin, Sara Fisher, Paul Dorris, Kathleen Koschmann, Carl Strother, Douglas Lafay-Cousin, Lucie Hansford, Jordan Gottardo, Nicholas Lane, Adam Coven, Scott Leach, James Drissi, Rachid Saab, Raya Chaney, Brooklyn Packer, Roger Jones, Blaise Goldman, Stewart Greiner, Robert Minturn, Jane Leary, Sarah Gass, David Fuller, Christine Ma, Jie
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givenname: Motasem surname: El-Ayadi fullname: El-Ayadi, Motasem organization: Children’s Cancer Hospital Egypt, Cairo, Egypt – sequence: 9 givenname: Kathleen surname: Dorris fullname: Dorris, Kathleen organization: Children’s Hospital Colorado, Denver, CO, USA – sequence: 10 givenname: Roger surname: Packer fullname: Packer, Roger organization: Children’s National Hospital, Washington, DC, USA – sequence: 11 givenname: Lindsey surname: Kilburn fullname: Kilburn, Lindsey organization: Children’s National Hospital, Washington, DC, USA – sequence: 12 givenname: Jane surname: Minturn fullname: Minturn, Jane organization: Children’s Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 13 givenname: Andrew surname: Dodgshun fullname: Dodgshun, Andrew organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 14 givenname: Sara surname: Parkin fullname: Parkin, Sara organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 15 givenname: Mercedes 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Canada – sequence: 30 givenname: Eric surname: Bouffet fullname: Bouffet, Eric organization: SickKids Hospital, Toronto, ON, Canada – sequence: 31 givenname: Jie surname: Ma fullname: Ma, Jie organization: Shanghai Xinhua Hospital, Shanghai, China – sequence: 32 givenname: Christopher surname: Tinkle fullname: Tinkle, Christopher organization: St. Jude Children’s Research Hospital, Memphis, TN, USA – sequence: 33 givenname: Michelle surname: Monje-Deisseroth fullname: Monje-Deisseroth, Michelle organization: Stanford Children’s Hospital, Palo Alto, CA, USA – sequence: 34 givenname: Paul surname: Fisher fullname: Fisher, Paul organization: Stanford Children’s Hospital, Palo Alto, CA, USA – sequence: 35 givenname: Karen surname: Tsui fullname: Tsui, Karen organization: Starship Children’s Health, Auckland, New Zealand – sequence: 36 givenname: David surname: Ziegler fullname: Ziegler, David organization: Sydney Children’s Hospital, Sydney, Australia – sequence: 37 givenname: Murali surname: Chintagumpala fullname: Chintagumpala, Murali organization: Texas Children’s Hospital, Houston, TX, USA – sequence: 38 givenname: Sridharan surname: Gururangan fullname: Gururangan, Sridharan organization: University of Florida, Gainesville, FL, USA – sequence: 39 givenname: Lars surname: Wagner fullname: Wagner, Lars organization: University of Kentucky, Lexington, KY, USA – sequence: 40 givenname: Carl surname: Koschmann fullname: Koschmann, Carl organization: University of Michigan, Ann Arbor, MI, USA – sequence: 41 givenname: Mariko surname: DeWire-Schottmiller fullname: DeWire-Schottmiller, Mariko organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 42 givenname: James surname: Leach fullname: Leach, James organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 43 givenname: Blaise surname: Jones fullname: Jones, Blaise organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 44 givenname: Christine surname: Fuller fullname: Fuller, Christine organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 45 givenname: Rachid surname: Drissi fullname: Drissi, Rachid organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 46 givenname: Brooklyn surname: Chaney fullname: Chaney, Brooklyn organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 47 givenname: Katie surname: Black fullname: Black, Katie organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 48 givenname: Maryam surname: Fouladi fullname: Fouladi, Maryam organization: Cincinnati Children’s Hospital, Cincinnati, OH, USA – sequence: 49 givenname: Douglas surname: Strother fullname: Strother, Douglas organization: University of Calgary, Calgary, AB, Canada
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