Correlation between IL-27p28 Genetic Polymorphisms and Risk of Allergic Rhinitis

Background and objectivesInterleukin 27 (IL-27) is a cytokine consisting of two subunits, p28 and EBI3, and is a key mediator in regulating the differentiation of TCD4 + cells while playing a crucial role in immune-related disorders. This study aims to elucidate the possible association between IL-2...

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Vydáno v:Gene expression Ročník 22; číslo 4; s. 281 - 287
Hlavní autoři: Koohyanizadeh, Farzaneh, Falahi, Sara, Mortazavi, Seyed Hamid Reza, Salari, Farhad, Rezaiemanesh, Alireza, Karaji, Ali Gorgin
Médium: Journal Article
Jazyk:angličtina
Vydáno: Sugar Land Xia & He Publishing 28.12.2023
Témata:
Allergic rhinitis
Allergies
Asthma
Bioinformatics
Cell differentiation
Cytokines
Dendritic cells
Enzyme-linked immunosorbent assay
Enzymes
Gene polymorphism
Genes
Genetic testing
Genotype & phenotype
Hay fever
Infectious diseases
Interleukin 27
Kurdish people
Nucleotides
Pathogenesis
Patients
Polymerase chain reaction
Polymorphism
Restriction fragment length polymorphism
Rhinitis
Risk
Serum levels
Single-nucleotide polymorphism
ISSN:1052-2166, 1555-3884
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Shrnutí:Background and objectivesInterleukin 27 (IL-27) is a cytokine consisting of two subunits, p28 and EBI3, and is a key mediator in regulating the differentiation of TCD4 + cells while playing a crucial role in immune-related disorders. This study aims to elucidate the possible association between IL-27p28 single nucleotide polymorphisms (SNPs), IL-27 serum levels, and the risk of allergic rhinitis (AR).Materials and methodsBlood samples were collected from 130 patients with AR and 130 healthy individuals, and DNA and serum were separated. The relationship between IL-27p28 SNPs (rs153109 and rs181206) and the risk of AR was evaluated using the polymerase chain reaction-restriction fragment length polymorphism method. The serum levels of IL-27 in the participants were determined using enzyme-linked immunosorbent assay.ResultsOur results did not show a significant relationship between IL-27p28 SNPs (rs153109 and rs181206) and the risk of AR or serum IL-27 levels. However, our results showed a significant decrease in the serum level of IL-27 in patients with AR (342 ± 299 pg/mL) compared to healthy subjects (455 ± 274 pg/mL) (p = 0.02).ConclusionOur results suggest that IL-27p28 SNPs (rs181206 and rs153109) are not associated with susceptibility to AR, but that decreased serum IL-27 levels may be associated with the development of AR.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1052-2166
1555-3884
DOI:10.14218/GE.2023.00019