CLINICAL, LABORATORY AND ECHOCARDIOGRAPHIC LEFT ATRIAL APPENDAGE THROMBUS PREDICTORS IN PATIENTS WITH ATRIAL FIBRILLATION

Background. The most common and persistent arrhythmia today is atrial fibrillation (AF). Decrease in blood flow velocity in the left atrium appendage (LAA), endothelial dysfunction and hemostatic system changes can cause the development of left atrium appendage thrombosis (LAAT), which is the main s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Zhurnal Grodnenskogo gosudarstvennogo medit͡s︡inskogo universiteta Jg. 23; H. 4; S. 331 - 336
Hauptverfasser: Kalatsei, L. V., Ibrahim, A., Fernando, Ch. E. S.
Format: Journal Article
Sprache:Belarussisch
Englisch
Veröffentlicht: Grodno State Medical University 01.09.2025
Schlagworte:
atrial fibrillation
echocardiography
left atrial appendage thrombus
left atrial volume index
nt-probnp
ISSN:2221-8785, 2413-0109
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract Background. The most common and persistent arrhythmia today is atrial fibrillation (AF). Decrease in blood flow velocity in the left atrium appendage (LAA), endothelial dysfunction and hemostatic system changes can cause the development of left atrium appendage thrombosis (LAAT), which is the main source of thromboembolism in patients with AF. Numerous studies have explored various clinical, echocardiographic, and laboratory parameters as potential predictors, however, the predictive power of these parameters is still insufficient for real clinical practice. Objective of the study was to evaluate predictive ability of clinical, laboratory and echocardiographic markers in diagnosis of LAAT in patients with non-valvular AF. Material and methods. The study included 100 patients with persistent non-valvular AF who were admitted for direct current cardioversion. According to transesophageal echocardiography results, patients were divided into 2 groups: patients with LAA thrombus «LAAT» (n=30) and without LAA thrombus «Non LAAT» (n=70). Results. Patients with LAAT had a significantly longer duration period of persistent AF (7 [4; 9] months vs 4 [3; 6] months, p=0.004) in comparison with patients without LAAT. Laboratory markers of patients in both groups had no significant differences except for GFR (p=0.047) and NT-proBNP level (p=0.011). According to the results of echocardiography, patients didn’t have differences in left atrial (LA) diameter and volume (p>0.05). However, LA volume index was higher in patients with LAAT (p=0.007). When conducting a ROC analysis, the NT-proBNP level of ≥ 1689 pg/ml showed the largest area under the ROC curve (0.747) as well as the highest specificity (92.6%). Conclusions. Patients with LAAT had longer duration of persistent AF, higher values of LA volume index, as well as higher NT-proBNP levels. Further use of these parameters could help predict LAAT development in patients with AF.
AbstractList Background. The most common and persistent arrhythmia today is atrial fibrillation (AF). Decrease in blood flow velocity in the left atrium appendage (LAA), endothelial dysfunction and hemostatic system changes can cause the development of left atrium appendage thrombosis (LAAT), which is the main source of thromboembolism in patients with AF. Numerous studies have explored various clinical, echocardiographic, and laboratory parameters as potential predictors, however, the predictive power of these parameters is still insufficient for real clinical practice. Objective of the study was to evaluate predictive ability of clinical, laboratory and echocardiographic markers in diagnosis of LAAT in patients with non-valvular AF. Material and methods. The study included 100 patients with persistent non-valvular AF who were admitted for direct current cardioversion. According to transesophageal echocardiography results, patients were divided into 2 groups: patients with LAA thrombus «LAAT» (n=30) and without LAA thrombus «Non LAAT» (n=70). Results. Patients with LAAT had a significantly longer duration period of persistent AF (7 [4; 9] months vs 4 [3; 6] months, p=0.004) in comparison with patients without LAAT. Laboratory markers of patients in both groups had no significant differences except for GFR (p=0.047) and NT-proBNP level (p=0.011). According to the results of echocardiography, patients didn’t have differences in left atrial (LA) diameter and volume (p>0.05). However, LA volume index was higher in patients with LAAT (p=0.007). When conducting a ROC analysis, the NT-proBNP level of ≥ 1689 pg/ml showed the largest area under the ROC curve (0.747) as well as the highest specificity (92.6%). Conclusions. Patients with LAAT had longer duration of persistent AF, higher values of LA volume index, as well as higher NT-proBNP levels. Further use of these parameters could help predict LAAT development in patients with AF.
Author Ibrahim, A.
Fernando, Ch. E. S.
Kalatsei, L. V.
Author_xml – sequence: 1
  givenname: L. V.
  orcidid: 0000-0001-5211-709X
  surname: Kalatsei
  fullname: Kalatsei, L. V.
– sequence: 2
  givenname: A.
  surname: Ibrahim
  fullname: Ibrahim, A.
– sequence: 3
  givenname: Ch. E. S.
  surname: Fernando
  fullname: Fernando, Ch. E. S.
BookMark eNo9UUlPhDAUbowmjst_6MGjaDdom3jpMMzQBIEwGOOpKQXMTEYx4MV_b1HHw1vylu8t3wU4fR_eOwBuMLojIZHinhCCA8FFGBBEvKIBCyjFXqITsCAM0wBhJE-9f6w8B9fTtEcIYUEijvECfMWZznWssluYqWVRqbqoXqDKVzCJ0yJW1UoXm0qVqY5hlqxrqOpKqwyqskzyldoksE6r4nH5tIVllax07Pu3UOewVLVO8noLn3WdHrvWelnpLPOpIr8CZ709TN31n70ET-ukjtMgKzbzQoHDnEaBs41gImwdZ_MZFDvcoJBR2THcNjZCTkaMNgz1QggShraRvOehlc5yZKWgl0D_4raD3ZuPcfdmxy8z2J35CQzjq7Hj584dOsMpIdLxtmHYsabtmhbzrm85l34aoqHHevjFcuMwTWPX_-NhZH5YMfOSZv61mVkxhBpmPCteIvoN52R3Kw
ContentType Journal Article
CorporateAuthor Grodno State Medical University, Grodno, Belarus
CorporateAuthor_xml – name: Grodno State Medical University, Grodno, Belarus
DBID AAYXX
CITATION
DOA
DOI 10.25298/2221-8785-2025-23-4-331-336
DatabaseName CrossRef
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: Acceso a contenido Full Text - Doaj
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
EISSN 2413-0109
EndPage 336
ExternalDocumentID oai_doaj_org_article_73229c7db41c4bdebd17efd7799e4035
10_25298_2221_8785_2025_23_4_331_336
GroupedDBID AAYXX
ALMA_UNASSIGNED_HOLDINGS
CITATION
GROUPED_DOAJ
VCL
VIT
ID FETCH-LOGICAL-c1736-cab8485dc74222131c1b05439e41dba60c9643b40f888255ab97f75a9ca70a983
IEDL.DBID DOA
ISSN 2221-8785
IngestDate Fri Oct 03 12:53:01 EDT 2025
Sat Nov 29 07:35:28 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language Belarusian
English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c1736-cab8485dc74222131c1b05439e41dba60c9643b40f888255ab97f75a9ca70a983
ORCID 0000-0001-5211-709X
OpenAccessLink https://doaj.org/article/73229c7db41c4bdebd17efd7799e4035
PageCount 6
ParticipantIDs doaj_primary_oai_doaj_org_article_73229c7db41c4bdebd17efd7799e4035
crossref_primary_10_25298_2221_8785_2025_23_4_331_336
PublicationCentury 2000
PublicationDate 2025-09-00
2025-09-01
PublicationDateYYYYMMDD 2025-09-01
PublicationDate_xml – month: 09
  year: 2025
  text: 2025-09-00
PublicationDecade 2020
PublicationTitle Zhurnal Grodnenskogo gosudarstvennogo medit͡s︡inskogo universiteta
PublicationYear 2025
Publisher Grodno State Medical University
Publisher_xml – name: Grodno State Medical University
SSID ssj0001826711
Score 2.3022056
Snippet Background. The most common and persistent arrhythmia today is atrial fibrillation (AF). Decrease in blood flow velocity in the left atrium appendage (LAA),...
SourceID doaj
crossref
SourceType Open Website
Index Database
StartPage 331
SubjectTerms atrial fibrillation
echocardiography
left atrial appendage thrombus
left atrial volume index
nt-probnp
Title CLINICAL, LABORATORY AND ECHOCARDIOGRAPHIC LEFT ATRIAL APPENDAGE THROMBUS PREDICTORS IN PATIENTS WITH ATRIAL FIBRILLATION
URI https://doaj.org/article/73229c7db41c4bdebd17efd7799e4035
Volume 23
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: Acceso a contenido Full Text - Doaj
  customDbUrl:
  eissn: 2413-0109
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0001826711
  issn: 2221-8785
  databaseCode: DOA
  dateStart: 20030101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhlNBLaGlDkj7QIceaWLbssY5arzcWuF7jdUhyEpJsQy9JSdNC_31H2k3YnnrpQToIxhLfjJkHwzeEXBSFYC5BDTj0FRE3OY-EAR7NWZLNM2rFucAz20DbFre3otsb9eV7wrb0wFvgLgEtTjgYLWeO23GyI4NpHgGEmHicBvZSjHr2kqlQXcGoGcLwXfR_DH_5IjsiF77vOUtEcflyiEaS4IavjNKU4cr_8k97NP7B36zekONdoEjl9oFvyYGd3pHfZaNaz2DwhTZy4QtM6_6OynZJq7Jel7JfqvVVL7talbSpVgOVQ69kQ2XXVe1SXlV0qPv118X1hiL0S1Wi_IaqlnZyUFU7bOiNGupnqZVa9JjshyrWe3K9qoayjnbDEyLHIM0jZ2zBi2x04Is8LGWOWQzPUkSNjdbksfNMXJbHM-bAmFcYK2CGzAhnIDaiSE_I4f3D_XRKaDIbl8PETTw6DrmwfBot5JlNwDiM-M5I9gyZ_r7lyNCYWwSotb9ce6i1h1onqeYaocaVn5GFx_dFxjNdhwPUv97pX_9L_-f_4yMfyOtgCKF37CM5fHr8OX0ir9yvp28_Hj8H0_oDy3rCuw
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CLINICAL%2C+LABORATORY+AND+ECHOCARDIOGRAPHIC+LEFT+ATRIAL+APPENDAGE+THROMBUS+PREDICTORS+IN+PATIENTS+WITH+ATRIAL+FIBRILLATION&rft.jtitle=Zhurnal+Grodnenskogo+gosudarstvennogo+medit%CD%A1s%EF%B8%A1inskogo+universiteta&rft.au=Kalatsei%2C+L.+V.&rft.au=Ibrahim%2C+A.&rft.au=Fernando%2C+Ch.+E.+S.&rft.date=2025-09-01&rft.issn=2221-8785&rft.eissn=2413-0109&rft.volume=23&rft.issue=4&rft.spage=331&rft.epage=336&rft_id=info:doi/10.25298%2F2221-8785-2025-23-4-331-336&rft.externalDBID=n%2Fa&rft.externalDocID=10_25298_2221_8785_2025_23_4_331_336
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2221-8785&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2221-8785&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2221-8785&client=summon