The role of the structure of the lamina cribrosa in the diagnosis and treatment of glaucoma. Structural and circulatory changes in the lamina cribrosa with aging and elevated intraocular pressure

The earliest damage in glaucoma starts in the posterior pole of the eye, where the axons of retinal ganglion cells, that form the optic nerve fibers, and retinal vessels pass through the connective tissue network called the lamina cribrosa (LC). Modern diagnostic techniques, such as optical coherenc...

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Bibliographic Details
Published in:Vestnik oftal'mologii Vol. 141; no. 1; p. 76
Main Authors: Kurysheva, N I, Kim, V Yu, Kim, V E, Plieva, Kh M
Format: Journal Article
Language:Russian
Published: Russia (Federation) 2025
Subjects:
Aging
Glaucoma - diagnosis
Glaucoma - physiopathology
Glaucoma - therapy
Humans
Intraocular Pressure - physiology
Optic Disk - blood supply
Optic Disk - diagnostic imaging
Optic Disk - pathology
Retinal Ganglion Cells - pathology
Tomography, Optical Coherence - methods
choroid
ocular blood flow
primary open-angle glaucoma
optical coherence tomography
choriocapillaris blood flow
lamina cribrosa
ISSN:0042-465X
Online Access:Get more information
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Summary:The earliest damage in glaucoma starts in the posterior pole of the eye, where the axons of retinal ganglion cells, that form the optic nerve fibers, and retinal vessels pass through the connective tissue network called the lamina cribrosa (LC). Modern diagnostic techniques, such as optical coherence tomography (OCT), enable the visualization of the LC and the assessment of blood flow within it, providing new opportunities for the diagnosis of glaucoma. This review highlights the anatomy and vascularization of the LC, along with the latest research findings obtained via OCT. The article details age-related changes in the LC and the impact of intraocular pressure (IOP) changes on its properties. A novel parameter, the lamina cribrosa curvature index (LCCI), reflecting LC deformation, has been shown to be the most important biomarker of glaucomatous damage.
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ISSN:0042-465X
DOI:10.17116/oftalma202514101176