CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS

To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology,  sixty patients have been examined  in  five equal groups, i.e., BA; hypothyroidism;  thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as ...

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Veröffentlicht in:Medit͡s︡inskai͡a︡ immunologii͡a Jg. 15; H. 2; S. 147 - 154
Hauptverfasser: Kamaeva, I. A., Shaporova, N. L., Gaiduk, I. M.
Format: Journal Article
Sprache:Englisch
Russisch
Veröffentlicht: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 14.07.2014
Schlagworte:
бронхиальная астма, гипотиреоз
иммуноглобулин e
интерлейкин
тиреотоксикоз
ISSN:1563-0625, 2313-741X
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Abstract To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology,  sixty patients have been examined  in  five equal groups, i.e., BA; hypothyroidism;  thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more  frequently  in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged  in BA patients,  than  in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum  IgE  levels were much  increased  in  the group with BA + hyperthyroidism. The  lowest IL-4/IFNγ ratio was revealed  in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher  in BA + hyperthyroidism group,  than  in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions dominating  in BA, whereas concomitant hypothyroidism may cause  a  reduction of Th2  immune  response.
AbstractList To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology,  sixty patients have been examined  in  five equal groups, i.e., BA; hypothyroidism;  thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more  frequently  in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged  in BA patients,  than  in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum  IgE  levels were much  increased  in  the group with BA + hyperthyroidism. The  lowest IL-4/IFNγ ratio was revealed  in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher  in BA + hyperthyroidism group,  than  in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions dominating  in BA, whereas concomitant hypothyroidism may cause  a  reduction of Th2  immune  response.
Author Shaporova, N. L.
Gaiduk, I. M.
Kamaeva, I. A.
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Snippet To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology,  sixty patients have been examined  in ...
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SubjectTerms бронхиальная астма, гипотиреоз
иммуноглобулин e
интерлейкин
тиреотоксикоз
Title CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
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