siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients

Restrictive element-1 silencing transcription factor (REST) is a key repressor of neuronal genes in stem cells and neuronal progenitor cells and its aberrant accumulation has been implicated in the pathophysiology of neurological disorders, such as Huntington's disease, epilepsy, and stroke. He...

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Vydané v:	Molecular therapy
Hlavní autori:	Guida, Natascia, Valsecchi, Valeria, Anzilotti, Serenella, Dubbioso, Raffaele, Cuomo, Ornella, Ruggiero, Silvia, Senerchia, Gianmaria, Iuzzolino, Valentina Virginia, Kolici, Xhesika, De Iesu, Nunzia, Pignataro, Giuseppe, Annunziato, Lucio, Formisano, Luigi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 16.10.2025
Predmet:	SOD1-G93A REST siRNA amyotrophic lateral sclerosis serum biomarker
ISSN:	1525-0024
On-line prístup:	Zistit podrobnosti o prístupe
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