siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients

Restrictive element-1 silencing transcription factor (REST) is a key repressor of neuronal genes in stem cells and neuronal progenitor cells and its aberrant accumulation has been implicated in the pathophysiology of neurological disorders, such as Huntington's disease, epilepsy, and stroke. He...

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Bibliographic Details

Published in:	Molecular therapy
Main Authors:	Guida, Natascia, Valsecchi, Valeria, Anzilotti, Serenella, Dubbioso, Raffaele, Cuomo, Ornella, Ruggiero, Silvia, Senerchia, Gianmaria, Iuzzolino, Valentina Virginia, Kolici, Xhesika, De Iesu, Nunzia, Pignataro, Giuseppe, Annunziato, Lucio, Formisano, Luigi
Format:	Journal Article
Language:	English
Published:	United States 16.10.2025
Subjects:	SOD1-G93A REST siRNA amyotrophic lateral sclerosis serum biomarker
ISSN:	1525-0024
Online Access:	Get more information
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