Alcohol as a risk factor for drug-induced diseases

Administration of a rational and safe drug therapy is one of the most challenging issues for healthcare professionals. The frequency of hospitalizations due to the adverse drug reactions in the years 2000 — 2015 was estimated at 6.3 (3.3—11.0 %) for developed countries and 5.5 % (1.1—16.9 %) for dev...

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Veröffentlicht in:Kachestvennai͡a︡ klinicheskai͡a︡ praktika H. 2; S. 52 - 66
Hauptverfasser: Sychev, D. A., Ostroumova, O. D., Pereverzev, A. P., Kochetkov, A. I., Ostroumova, T. M., Ebzeeva, E. Yu, Klepikova, M. V.
Format: Journal Article
Sprache:Englisch
Russisch
Veröffentlicht: Izdatelstvo OKI 13.08.2021
Schlagworte:
алкоголь
безопасность
взаимодействия
лекарственно-индуцированные заболевания
лекарственные средства
нежелательные реакции
ISSN:2588-0519, 2618-8473
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Abstract Administration of a rational and safe drug therapy is one of the most challenging issues for healthcare professionals. The frequency of hospitalizations due to the adverse drug reactions in the years 2000 — 2015 was estimated at 6.3 (3.3—11.0 %) for developed countries and 5.5 % (1.1—16.9 %) for developing countries. It is known that alcohol intake is a risk factor for many socially significant diseases, including arterial hypertension, coronary heart disease, chronic heart failure, etc., however, many doctors pay insufficient attention to the fact that many drugs, for example, beta-blockers, antidepressants, bezodisepines, calcium antagonists, can interact with alcohol when consumed simultaneously and, thus, increase the risks of adverse drug reactions. There are 2 main types of interactions between alcohol and drugs: pharmacokinetic (at the stage of absorption, distribution, metabolism and elimination) and pharmacodynamic (at the stage of effects and receptors). For example: the simultaneous intake of alcohol and paracetamol leads to the formation of toxic metabolites due to the induction of cytochrome P450 isoenzymes by alcohol. Another example is decrease in presystemic elimination and stimulation of the metabolism of tricyclic antidepressants; an increase in the elimination of imipramine and desipramine in patients with chronic alcoholism after detoxification therapy, and so on. In this article, the authors analyzed and systematized data from open literature sources in order to inform health care professionals about the possible risks associated with the interaction of alcohol and drugs and various pharmacological groups.
AbstractList Administration of a rational and safe drug therapy is one of the most challenging issues for healthcare professionals. The frequency of hospitalizations due to the adverse drug reactions in the years 2000 — 2015 was estimated at 6.3 (3.3—11.0 %) for developed countries and 5.5 % (1.1—16.9 %) for developing countries. It is known that alcohol intake is a risk factor for many socially significant diseases, including arterial hypertension, coronary heart disease, chronic heart failure, etc., however, many doctors pay insufficient attention to the fact that many drugs, for example, beta-blockers, antidepressants, bezodisepines, calcium antagonists, can interact with alcohol when consumed simultaneously and, thus, increase the risks of adverse drug reactions. There are 2 main types of interactions between alcohol and drugs: pharmacokinetic (at the stage of absorption, distribution, metabolism and elimination) and pharmacodynamic (at the stage of effects and receptors). For example: the simultaneous intake of alcohol and paracetamol leads to the formation of toxic metabolites due to the induction of cytochrome P450 isoenzymes by alcohol. Another example is decrease in presystemic elimination and stimulation of the metabolism of tricyclic antidepressants; an increase in the elimination of imipramine and desipramine in patients with chronic alcoholism after detoxification therapy, and so on. In this article, the authors analyzed and systematized data from open literature sources in order to inform health care professionals about the possible risks associated with the interaction of alcohol and drugs and various pharmacological groups.
Author Ostroumova, O. D.
Ostroumova, T. M.
Pereverzev, A. P.
Sychev, D. A.
Kochetkov, A. I.
Ebzeeva, E. Yu
Klepikova, M. V.
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Cites_doi 10.1016/B978-0-12-387817-5.00016-9
10.1186/1471-2318-14-57
10.1007/s40262-014-0190-x
10.30895/2312-7821-2021-9-1-15-24
10.1046/j.1532-5415.2002.50607.x
10.1056/NEJM198204083061406
10.37573/9781585285310
10.18565/pharmateca.2020.5.77-84
10.4103/0971-5916.162093
10.1007/s40264-016-0444-7
10.1111/jgs.13787
10.2165/00002018-199411040-00002
10.22541/au.158931082.22879201
10.1111/j.1532-5415.1995.tb05567.x
10.1111/bcp.12314
10.1177/106002809302700702
10.1345/aph.1L037
10.1111/j.1572-0241.1999.01517.x
10.1111/j.1365-2710.2006.00744.x
10.1046/j.1365-2710.1998.00175.x
10.1002/pds.721
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References ref13
ref35
ref12
ref34
ref15
ref14
ref36
ref31
ref30
ref11
ref33
ref10
ref32
ref2
ref1
ref17
ref16
ref19
ref18
ref24
ref23
ref26
ref25
ref20
ref22
ref21
ref28
ref27
ref29
ref8
ref7
ref9
ref4
ref3
ref6
ref5
References_xml – ident: ref3
– ident: ref7
– ident: ref20
– ident: ref14
  doi: 10.1016/B978-0-12-387817-5.00016-9
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  doi: 10.1186/1471-2318-14-57
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  doi: 10.1007/s40262-014-0190-x
– ident: ref12
  doi: 10.30895/2312-7821-2021-9-1-15-24
– ident: ref10
  doi: 10.1046/j.1532-5415.2002.50607.x
– ident: ref26
  doi: 10.1056/NEJM198204083061406
– ident: ref11
  doi: 10.37573/9781585285310
– ident: ref2
  doi: 10.18565/pharmateca.2020.5.77-84
– ident: ref13
  doi: 10.4103/0971-5916.162093
– ident: ref1
  doi: 10.1007/s40264-016-0444-7
– ident: ref19
– ident: ref28
  doi: 10.1111/jgs.13787
– ident: ref24
  doi: 10.2165/00002018-199411040-00002
– ident: ref17
– ident: ref34
– ident: ref15
– ident: ref30
– ident: ref36
– ident: ref22
  doi: 10.22541/au.158931082.22879201
– ident: ref23
  doi: 10.1111/j.1532-5415.1995.tb05567.x
– ident: ref4
  doi: 10.1111/bcp.12314
– ident: ref9
  doi: 10.1177/106002809302700702
– ident: ref6
  doi: 10.1345/aph.1L037
– ident: ref25
  doi: 10.1111/j.1572-0241.1999.01517.x
– ident: ref5
  doi: 10.1111/j.1365-2710.2006.00744.x
– ident: ref21
– ident: ref35
  doi: 10.1046/j.1365-2710.1998.00175.x
– ident: ref27
  doi: 10.1002/pds.721
– ident: ref8
– ident: ref18
– ident: ref16
– ident: ref33
– ident: ref31
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SubjectTerms алкоголь
безопасность
взаимодействия
лекарственно-индуцированные заболевания
лекарственные средства
нежелательные реакции
Title Alcohol as a risk factor for drug-induced diseases
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