The pharmacoepidemiology of potential drug-drug interactions in patients with psychiatric disorders
Actuality . Drug safety issues in patients with psychiatric disorders are relevant due to specifics of clinical pharmacology of the medicinal products used, possible treatment-resistance of mental illnesses and concomitant use of multiple antipsychotic drugs. One of the aspects of treatment safety i...
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| Published in: | Kachestvennai͡a︡ klinicheskai͡a︡ praktika no. 3; pp. 85 - 92 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English Russian |
| Published: |
Izdatelstvo OKI
27.09.2020
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| Subjects: | |
| ISSN: | 2588-0519, 2618-8473 |
| Online Access: | Get full text |
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| Summary: | Actuality
. Drug safety issues in patients with psychiatric disorders are relevant due to specifics of clinical pharmacology of the medicinal products used, possible treatment-resistance of mental illnesses and concomitant use of multiple antipsychotic drugs. One of the aspects of treatment safety is a prediction of drug-drug interactions.
The aim
of the study was to analyze potential drug-drug interactions in patients with psychiatric disorders.
Materials and methods.
The study enrolled 500 patients with psychiatric disorders in two age-related groups. Drug therapy was analyzed to reveal potential cases of drug-drug interactions.
Results.
A total of 1 031 cases of the use of drug combinations leading to drug-drug interactions of various clinical significance were revealed in 72.4 % of patients. There were significant differences between two age-related groups in respect of the specifics of medications use and clinical significance of drug combinations.
Conclusion.
Prediction of drug-drug interactions is likely to ensure improved drug safety in patients with psychiatric disorders. |
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| ISSN: | 2588-0519 2618-8473 |
| DOI: | 10.37489/2588-0519-2020-3-85-92 |