Functional requirements for guided bone regeneration/guided tissue regeneration membrane design: Progress and challenges

Guided tissue regeneration (GTR) and guided bone regeneration (GBR) membranes are critical for reconstructing periodontal/bone defects, but existing membranes face limitations in osteogenic potential, antibacterial efficacy, degradation kinetics, mechanical stability, and immunomodulation within the...

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Vydáno v:Periodontology 2000
Hlavní autoři: Zhan, Huilu, Shi, Ruijianghan, Ni, Haohao, Li, Haiyan, Yuan, Changyong, Lin, Kaili, Sculean, Anton, Miron, Richard J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Denmark 12.11.2025
Témata:
guided bone regeneration
bone regeneration
membrane design
periodontal regeneration
functional requirements
guided tissue regeneration
ISSN:0906-6713, 1600-0757, 1600-0757
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Abstract Guided tissue regeneration (GTR) and guided bone regeneration (GBR) membranes are critical for reconstructing periodontal/bone defects, but existing membranes face limitations in osteogenic potential, antibacterial efficacy, degradation kinetics, mechanical stability, and immunomodulation within the complex oral microenvironment. This review aims to explore cellular interactions between alveolar bone regenerative cells and GBR/GTR membranes, membrane design strategies based on biological functions, and advancements in material engineering to overcome current clinical challenges. A comprehensive search strategy was implemented across PubMed, Scopus, Web of Science databases, as well as clinical trials registers. Data pertinent to membrane synthetic methodology, biological behavior, tissue regeneration outcomes were retrieved from the original studies. A qualitative assessment was performed. Overall, ideal GBR/GTR membranes must meet several functional requirements: (i) Clinical necessities include biocompatibility, selective permeability for nutrient exchange, and clinical operability. GTR aims to create and maintain a stable isolated space to protect blood clots, thereby enabling blood clots and the newly formed tissue to effectively block the migration of epithelial cells. GBR demands rigid space maintenance to resist mucosal compression in edentulous ridges, with greater emphasis on mechanical stability for large bone defects. Degradation kinetics must align with slower bone formation (3–6 months). (ii) Appropriate surface properties (roughness, morphology, stiffness, wettability, charge) and porosity/pore size are critical for cell behavior. (iii) Membrane‐based biological regulation can promote cell adhesion and migration, and balance osteoclastogenesis and osteogenesis. Optimization strategies include incorporating bioactive substances for bone regeneration, immunomodulatory agents for anti‐inflammatory responses, and antibacterial additives for clinical performance. GBR/GTR membranes require multifunctional integration of barrier functionality, tailored biodegradation, mechanical robustness, and proactive bioactivity (osteogenic, angiogenic, immunomodulatory, and antibacterial). Future designs must prioritize understanding cell‐material interactions to develop membranes that dynamically synchronize with the regenerative microenvironment. This review provides a foundation for developing next‐generation membranes that effectively address complex oral microenvironment challenges and significantly improve clinical outcomes in bone defect reconstruction. Optimized membranes will enhance space maintenance, reduce infection rates, mitigate premature degradation, and improve predictability in reconstructing periodontal and alveolar bone defects, ultimately advancing regenerative outcomes in implant dentistry and periodontal surgery.
AbstractList Guided tissue regeneration (GTR) and guided bone regeneration (GBR) membranes are critical for reconstructing periodontal/bone defects, but existing membranes face limitations in osteogenic potential, antibacterial efficacy, degradation kinetics, mechanical stability, and immunomodulation within the complex oral microenvironment. This review aims to explore cellular interactions between alveolar bone regenerative cells and GBR/GTR membranes, membrane design strategies based on biological functions, and advancements in material engineering to overcome current clinical challenges. A comprehensive search strategy was implemented across PubMed, Scopus, Web of Science databases, as well as clinical trials registers. Data pertinent to membrane synthetic methodology, biological behavior, tissue regeneration outcomes were retrieved from the original studies. A qualitative assessment was performed. Overall, ideal GBR/GTR membranes must meet several functional requirements: (i) Clinical necessities include biocompatibility, selective permeability for nutrient exchange, and clinical operability. GTR aims to create and maintain a stable isolated space to protect blood clots, thereby enabling blood clots and the newly formed tissue to effectively block the migration of epithelial cells. GBR demands rigid space maintenance to resist mucosal compression in edentulous ridges, with greater emphasis on mechanical stability for large bone defects. Degradation kinetics must align with slower bone formation (3-6 months). (ii) Appropriate surface properties (roughness, morphology, stiffness, wettability, charge) and porosity/pore size are critical for cell behavior. (iii) Membrane-based biological regulation can promote cell adhesion and migration, and balance osteoclastogenesis and osteogenesis. Optimization strategies include incorporating bioactive substances for bone regeneration, immunomodulatory agents for anti-inflammatory responses, and antibacterial additives for clinical performance. GBR/GTR membranes require multifunctional integration of barrier functionality, tailored biodegradation, mechanical robustness, and proactive bioactivity (osteogenic, angiogenic, immunomodulatory, and antibacterial). Future designs must prioritize understanding cell-material interactions to develop membranes that dynamically synchronize with the regenerative microenvironment. This review provides a foundation for developing next-generation membranes that effectively address complex oral microenvironment challenges and significantly improve clinical outcomes in bone defect reconstruction. Optimized membranes will enhance space maintenance, reduce infection rates, mitigate premature degradation, and improve predictability in reconstructing periodontal and alveolar bone defects, ultimately advancing regenerative outcomes in implant dentistry and periodontal surgery.
Guided tissue regeneration (GTR) and guided bone regeneration (GBR) membranes are critical for reconstructing periodontal/bone defects, but existing membranes face limitations in osteogenic potential, antibacterial efficacy, degradation kinetics, mechanical stability, and immunomodulation within the complex oral microenvironment. This review aims to explore cellular interactions between alveolar bone regenerative cells and GBR/GTR membranes, membrane design strategies based on biological functions, and advancements in material engineering to overcome current clinical challenges. A comprehensive search strategy was implemented across PubMed, Scopus, Web of Science databases, as well as clinical trials registers. Data pertinent to membrane synthetic methodology, biological behavior, tissue regeneration outcomes were retrieved from the original studies. A qualitative assessment was performed. Overall, ideal GBR/GTR membranes must meet several functional requirements: (i) Clinical necessities include biocompatibility, selective permeability for nutrient exchange, and clinical operability. GTR aims to create and maintain a stable isolated space to protect blood clots, thereby enabling blood clots and the newly formed tissue to effectively block the migration of epithelial cells. GBR demands rigid space maintenance to resist mucosal compression in edentulous ridges, with greater emphasis on mechanical stability for large bone defects. Degradation kinetics must align with slower bone formation (3-6 months). (ii) Appropriate surface properties (roughness, morphology, stiffness, wettability, charge) and porosity/pore size are critical for cell behavior. (iii) Membrane-based biological regulation can promote cell adhesion and migration, and balance osteoclastogenesis and osteogenesis. Optimization strategies include incorporating bioactive substances for bone regeneration, immunomodulatory agents for anti-inflammatory responses, and antibacterial additives for clinical performance. GBR/GTR membranes require multifunctional integration of barrier functionality, tailored biodegradation, mechanical robustness, and proactive bioactivity (osteogenic, angiogenic, immunomodulatory, and antibacterial). Future designs must prioritize understanding cell-material interactions to develop membranes that dynamically synchronize with the regenerative microenvironment. This review provides a foundation for developing next-generation membranes that effectively address complex oral microenvironment challenges and significantly improve clinical outcomes in bone defect reconstruction. Optimized membranes will enhance space maintenance, reduce infection rates, mitigate premature degradation, and improve predictability in reconstructing periodontal and alveolar bone defects, ultimately advancing regenerative outcomes in implant dentistry and periodontal surgery.Guided tissue regeneration (GTR) and guided bone regeneration (GBR) membranes are critical for reconstructing periodontal/bone defects, but existing membranes face limitations in osteogenic potential, antibacterial efficacy, degradation kinetics, mechanical stability, and immunomodulation within the complex oral microenvironment. This review aims to explore cellular interactions between alveolar bone regenerative cells and GBR/GTR membranes, membrane design strategies based on biological functions, and advancements in material engineering to overcome current clinical challenges. A comprehensive search strategy was implemented across PubMed, Scopus, Web of Science databases, as well as clinical trials registers. Data pertinent to membrane synthetic methodology, biological behavior, tissue regeneration outcomes were retrieved from the original studies. A qualitative assessment was performed. Overall, ideal GBR/GTR membranes must meet several functional requirements: (i) Clinical necessities include biocompatibility, selective permeability for nutrient exchange, and clinical operability. GTR aims to create and maintain a stable isolated space to protect blood clots, thereby enabling blood clots and the newly formed tissue to effectively block the migration of epithelial cells. GBR demands rigid space maintenance to resist mucosal compression in edentulous ridges, with greater emphasis on mechanical stability for large bone defects. Degradation kinetics must align with slower bone formation (3-6 months). (ii) Appropriate surface properties (roughness, morphology, stiffness, wettability, charge) and porosity/pore size are critical for cell behavior. (iii) Membrane-based biological regulation can promote cell adhesion and migration, and balance osteoclastogenesis and osteogenesis. Optimization strategies include incorporating bioactive substances for bone regeneration, immunomodulatory agents for anti-inflammatory responses, and antibacterial additives for clinical performance. GBR/GTR membranes require multifunctional integration of barrier functionality, tailored biodegradation, mechanical robustness, and proactive bioactivity (osteogenic, angiogenic, immunomodulatory, and antibacterial). Future designs must prioritize understanding cell-material interactions to develop membranes that dynamically synchronize with the regenerative microenvironment. This review provides a foundation for developing next-generation membranes that effectively address complex oral microenvironment challenges and significantly improve clinical outcomes in bone defect reconstruction. Optimized membranes will enhance space maintenance, reduce infection rates, mitigate premature degradation, and improve predictability in reconstructing periodontal and alveolar bone defects, ultimately advancing regenerative outcomes in implant dentistry and periodontal surgery.
Author Zhan, Huilu
Yuan, Changyong
Miron, Richard J.
Lin, Kaili
Li, Haiyan
Shi, Ruijianghan
Sculean, Anton
Ni, Haohao
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  organization: Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
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  surname: Ni
  fullname: Ni, Haohao
  organization: The First School of Clinical Medicine Zhejiang Chinese Medical University Hangzhou China
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  surname: Li
  fullname: Li, Haiyan
  organization: Biomedical Engineering Department, School of Engineering, STEM College RMIT University Melbourne Victoria Australia
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  givenname: Changyong
  surname: Yuan
  fullname: Yuan, Changyong
  organization: School of Stomatology, Xuzhou Medical University Affiliated Stomatological Hospital of Xuzhou Medical University Xuzhou China
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  givenname: Kaili
  orcidid: 0000-0002-1900-9641
  surname: Lin
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  givenname: Anton
  orcidid: 0000-0003-2836-5477
  surname: Sculean
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  organization: Department of Periodontology University of Bern Bern Switzerland
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  givenname: Richard J.
  orcidid: 0000-0003-3290-3418
  surname: Miron
  fullname: Miron, Richard J.
  organization: Department of Periodontology University of Bern Bern Switzerland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/41221631$$D View this record in MEDLINE/PubMed
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bone regeneration
membrane design
periodontal regeneration
functional requirements
guided tissue regeneration
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PublicationPlace Denmark
PublicationPlace_xml – name: Denmark
PublicationTitle Periodontology 2000
PublicationTitleAlternate Periodontol 2000
PublicationYear 2025
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Snippet Guided tissue regeneration (GTR) and guided bone regeneration (GBR) membranes are critical for reconstructing periodontal/bone defects, but existing membranes...
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