Specifics of motivation of volunteers participating in in a clinical trial of the COVID-19 vaccine
Background. The pandemic coronavirus infection has contributed to the development of effective preventive methods to slow the spread of the virus. Mass vaccination is the only way to protect oneself from infection. The development of drugs, including vaccines, involves clinical trials (CT). The prob...
Uloženo v:
| Vydáno v: | Kachestvennai͡a︡ klinicheskai͡a︡ praktika číslo 4; s. 4 - 12 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina ruština |
| Vydáno: |
Izdatelstvo OKI
01.03.2023
|
| Témata: | |
| ISSN: | 2588-0519, 2618-8473 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Background. The pandemic coronavirus infection has contributed to the development of effective preventive methods to slow the spread of the virus. Mass vaccination is the only way to protect oneself from infection. The development of drugs, including vaccines, involves clinical trials (CT). The problem of conducting a CT is recruiting the necessary number of volunteers. Goal: to identify specifics of motivation of patients participating in the clinical trial of COVID-19 vaccines, as it is a very important medical and sociological issue requiring more detailed study. Materials and Methods. The results of an anonymous questionnaire survey of volunteers participating in the “EpiVacCorona” vaccine CT are presented. Overall, 203 questionnaires were analyzed, containing 19 questions answered by the residents of Kaliningrad, aged 20 to 84 years. At the stage of completion of participation in the clinical trial, information was obtained about the respondent’s attitudes to the trial, the main factors of motivation or demotivation to participate, the degree of their trust in the trial. Results. Information disseminated through the employer was an effective way to organize patient recruitment for the vaccine CT; the effectiveness of using the media was quite low. The positives of participation in the CT for volunteers were ethical considerations. Negatives for participants were the risks associated with adverse reactions or receiving a placebo. Relatives had the greatest influence on the volunteers’ decision to participate in the CT, and medical professionals, media personalities, and scientists had less influence. Conclusion. The results will help to improve patient recruitment, patient awareness of the CT, and the benefits to medicine and society. Motivating and demotivating factors will improve patient recruitment. |
|---|---|
| AbstractList | Background. The pandemic coronavirus infection has contributed to the development of effective preventive methods to slow the spread of the virus. Mass vaccination is the only way to protect oneself from infection. The development of drugs, including vaccines, involves clinical trials (CT). The problem of conducting a CT is recruiting the necessary number of volunteers. Goal: to identify specifics of motivation of patients participating in the clinical trial of COVID-19 vaccines, as it is a very important medical and sociological issue requiring more detailed study. Materials and Methods. The results of an anonymous questionnaire survey of volunteers participating in the “EpiVacCorona” vaccine CT are presented. Overall, 203 questionnaires were analyzed, containing 19 questions answered by the residents of Kaliningrad, aged 20 to 84 years. At the stage of completion of participation in the clinical trial, information was obtained about the respondent’s attitudes to the trial, the main factors of motivation or demotivation to participate, the degree of their trust in the trial. Results. Information disseminated through the employer was an effective way to organize patient recruitment for the vaccine CT; the effectiveness of using the media was quite low. The positives of participation in the CT for volunteers were ethical considerations. Negatives for participants were the risks associated with adverse reactions or receiving a placebo. Relatives had the greatest influence on the volunteers’ decision to participate in the CT, and medical professionals, media personalities, and scientists had less influence. Conclusion. The results will help to improve patient recruitment, patient awareness of the CT, and the benefits to medicine and society. Motivating and demotivating factors will improve patient recruitment. |
| Author | Belousova, Y. D. Kislova, E. D. Rafalsky, V. V. |
| Author_xml | – sequence: 1 givenname: Y. D. orcidid: 0000-0001-9333-1244 surname: Belousova fullname: Belousova, Y. D. organization: Immanuel Kant Baltic Federal University – sequence: 2 givenname: V. V. orcidid: 0000-0002-2503-9580 surname: Rafalsky fullname: Rafalsky, V. V. organization: Immanuel Kant Baltic Federal University – sequence: 3 givenname: E. D. orcidid: 0000-0001-9896-4462 surname: Kislova fullname: Kislova, E. D. organization: Immanuel Kant Baltic Federal University |
| BookMark | eNo9UNtqwzAMNaODdV1_YeQHstmyEzuPo7sVCn3Y5dU4itx5pHFIssL-fkm7jSN01wGdSzZrYkOMXQt-I7UyxS1kxqQ8E0UKHCBVIwScsTnkwqRGaTkb87-dC7bs-1BypXTGpdZzVr60hMEH7JPok30cwsENITZTdYj1VzMQdX3Sum4IGNpx1uyS0EzmEqxDE9DVydCF0Y8nwwclq-37-j4VRXJwiKGhK3buXd3T8jcu2Nvjw-vqOd1sn9aru02KIheQFii8ygikQCmRVyYjoWXByRHpEgx4j7nAwoDkY1NXuSkVOhJQqFJgJRdsfeKtovu0bRf2rvu20QV7bMRuZ49f1GShUj7HDAkQlHS-hJI8Cme80dI4OXLlJy7sYt935P_5BLdH4e0kqp1EtZPwVo0QIH8ASe94qw |
| Cites_doi | 10.3390/ijms21249775 10.52586/5024 10.1016/j.jsps.2022.01.008 10.1186/s12874-020-00949-5 10.1016/j.pmedr.2021.101350 10.1038/s41591-020-1124-9 10.1016/j.msard.2021.103163 10.1016/j.msard.2021.103450 10.1136/bmjopen-2016-015276 10.1136/medethics-2020-106501 10.1371/journal.pntd.0008961 10.3389/fmed.2021.608959 10.3389/fimmu.2021.658519 10.1007/s40199-020-00371-8 10.1016/j.vaccine.2020.09.041 10.1186/s12888-022-04073-0 10.1186/s12889-021-12385-1 10.3389/fimmu.2020.585354 10.2147/PPA.S284385 |
| ContentType | Journal Article |
| DBID | AAYXX CITATION DOA |
| DOI | 10.37489/2588-0519-2022-4-4-12 |
| DatabaseName | CrossRef Directory of Open Access Journals |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2618-8473 |
| EndPage | 12 |
| ExternalDocumentID | oai_doaj_org_article_2d4f6c5ce2c243afb2befc1a8f8738a3 10_37489_2588_0519_2022_4_4_12 |
| GroupedDBID | AAYXX ALMA_UNASSIGNED_HOLDINGS CITATION GROUPED_DOAJ |
| ID | FETCH-LOGICAL-c1612-9c1f45e231c33c0d85e17390eaee7b282ffc61c982300ea7d68b4cae1294b1cd3 |
| IEDL.DBID | DOA |
| ISSN | 2588-0519 |
| IngestDate | Fri Oct 03 12:46:25 EDT 2025 Sat Nov 29 05:01:01 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English Russian |
| License | https://www.clinvest.ru/jour/about/editorialPolicies#openAccessPolicy |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c1612-9c1f45e231c33c0d85e17390eaee7b282ffc61c982300ea7d68b4cae1294b1cd3 |
| ORCID | 0000-0001-9896-4462 0000-0002-2503-9580 0000-0001-9333-1244 |
| OpenAccessLink | https://doaj.org/article/2d4f6c5ce2c243afb2befc1a8f8738a3 |
| PageCount | 9 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_2d4f6c5ce2c243afb2befc1a8f8738a3 crossref_primary_10_37489_2588_0519_2022_4_4_12 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-03-01 |
| PublicationDateYYYYMMDD | 2023-03-01 |
| PublicationDate_xml | – month: 03 year: 2023 text: 2023-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Kachestvennai͡a︡ klinicheskai͡a︡ praktika |
| PublicationYear | 2023 |
| Publisher | Izdatelstvo OKI |
| Publisher_xml | – name: Izdatelstvo OKI |
| References | ref13 ref12 ref15 ref14 ref20 ref11 ref10 ref2 ref1 ref17 ref16 ref19 ref18 ref8 ref7 ref9 ref4 ref3 ref6 ref5 |
| References_xml | – ident: ref3 doi: 10.3390/ijms21249775 – ident: ref8 doi: 10.52586/5024 – ident: ref2 – ident: ref9 doi: 10.1016/j.jsps.2022.01.008 – ident: ref13 doi: 10.1186/s12874-020-00949-5 – ident: ref6 doi: 10.1016/j.pmedr.2021.101350 – ident: ref19 doi: 10.1038/s41591-020-1124-9 – ident: ref14 doi: 10.1016/j.msard.2021.103163 – ident: ref17 doi: 10.1016/j.msard.2021.103450 – ident: ref15 doi: 10.1136/bmjopen-2016-015276 – ident: ref12 doi: 10.1136/medethics-2020-106501 – ident: ref4 doi: 10.1371/journal.pntd.0008961 – ident: ref5 doi: 10.3389/fmed.2021.608959 – ident: ref10 doi: 10.3389/fimmu.2021.658519 – ident: ref7 doi: 10.1007/s40199-020-00371-8 – ident: ref20 doi: 10.1016/j.vaccine.2020.09.041 – ident: ref1 doi: 10.1186/s12888-022-04073-0 – ident: ref18 doi: 10.1186/s12889-021-12385-1 – ident: ref11 doi: 10.3389/fimmu.2020.585354 – ident: ref16 doi: 10.2147/PPA.S284385 |
| SSID | ssib044750377 ssj0002874179 |
| Score | 2.2116435 |
| Snippet | Background. The pandemic coronavirus infection has contributed to the development of effective preventive methods to slow the spread of the virus. Mass... |
| SourceID | doaj crossref |
| SourceType | Open Website Index Database |
| StartPage | 4 |
| SubjectTerms | covid-19 вакцина клиническое исследование коронавирусная инфекция мотивация участия в клиническом исследовании социологическое исследование |
| Title | Specifics of motivation of volunteers participating in in a clinical trial of the COVID-19 vaccine |
| URI | https://doaj.org/article/2d4f6c5ce2c243afb2befc1a8f8738a3 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: Directory of Open Access Journals (DOAJ) customDbUrl: eissn: 2618-8473 dateEnd: 20241231 omitProxy: false ssIdentifier: ssj0002874179 issn: 2588-0519 databaseCode: DOA dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2618-8473 dateEnd: 99991231 omitProxy: false ssIdentifier: ssib044750377 issn: 2588-0519 databaseCode: M~E dateStart: 20010101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NS8MwGA4yRLyInzi_yMFrWZukbXrUuaHgpgcdu4UkTWSC25jbjv523zetZZ68SEuhoV88Cc3zJm-eh5BrmRbGGJ9FyB4i9LCONDdFJBhzaWwglgtjuqPHfDiU43HxvGH1hTlhlTxwBVyHlcJnNrWOWSa49oYZ522ipZc5lzrofMZ5sRFMQUtCFbuY1yss38MQUo5WW-g0l0LTQN5SLRcO6iudphAaDQRnIkItv1891Yagf-h5-vtkr6aM9Kb61AOytVgdkp1BPSl-REzwkMeMHzrz9KMxLMMz_PkAdMDx6Fw3GdTTNzqZ4q7pz8pIGuw78BZghLT7NHq4A2DpWlt8yTF57fdeuvdRbZ0QWaBwLCps4kXqgLxZzm1cytQlOS9ip53LDYRZ3tsssQVOs0FhXmbSCKsd9P7CJLbkJ6Q1nU3dKaE5XGdsKgzzBQSDUpZlyYQWmbaiBELYJp0fmNS8UshQEFkEYBUCqxBYhcAqAVvC2uQW0WyuRoXrUAD1rup6V3_V-9l_POSc7KJ9fJVTdkFay8XKXZJtu15OPhdXoUnBcfDV-wa_4Mzc |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Specifics+of+motivation+of+volunteers+participating+in+in+a+clinical+trial+of+the+COVID-19+vaccine&rft.jtitle=Kachestvennai%CD%A1a%EF%B8%A1+klinicheskai%CD%A1a%EF%B8%A1+praktika&rft.au=Belousova%2C+Y.+D.&rft.au=Rafalsky%2C+V.+V.&rft.au=Kislova%2C+E.+D.&rft.date=2023-03-01&rft.issn=2588-0519&rft.eissn=2618-8473&rft.issue=4&rft.spage=4&rft.epage=12&rft_id=info:doi/10.37489%2F2588-0519-2022-4-4-12&rft.externalDBID=n%2Fa&rft.externalDocID=10_37489_2588_0519_2022_4_4_12 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2588-0519&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2588-0519&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2588-0519&client=summon |