N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.Novel N-substituted tetrahydro-2,4-dioxoqui...

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Veröffentlicht in:Pharmazie Jg. 62; H. 8; S. 636
Hauptverfasser: Rakowitz, D, Gmeiner, A, Matuszczak, B
Format: Journal Article
Sprache:Englisch
Veröffentlicht: 27.11.2007
ISSN:0031-7144
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Zusammenfassung:Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
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ISSN:0031-7144
DOI:10.1002/chin.200748146