Comparative investigation of the transport and deposition of nebulized particles in pediatric mouth-throat airways with tonsil hypertrophy at different severity levels

[Display omitted] Pediatric allergic asthma necessitates efficient aerosol drug delivery through the mouth-throat (MT) airway. Tonsil hypertrophy (TH), a common comorbidity, causes oropharyngeal obstruction, potentially compromising inhalation therapy. This study quantitatively investigated the impa...

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Veröffentlicht in:	International journal of pharmaceutics Jg. 686; S. 126365
Hauptverfasser:	Yang, Feilun, Ma, Ruiping, Wang, Yusheng, Li, Zehui, Shi, Yewen, Feng, Xin, Zheng, Guoxi, Ren, Xiaoyong, Cheng, Shaokoon, Dong, Jingliang, Zhang, Ya
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 25.12.2025
Schlagworte:	Administration, Inhalation Aerosol deposition Aerosols Asthma - drug therapy Child Child, Preschool Computational Fluid-Particle Dynamics (CFPD) Drug delivery Drug Delivery Systems Female Humans Hypertrophy Male Nebulization Nebulizers and Vaporizers Oropharynx - metabolism Palatine Tonsil - pathology Particle Size Pediatric airway Pharynx - metabolism Severity of Illness Index Tonsil hypertrophy (TH) CFD DPM DE Q3 CFPD Nebulization Drug delivery STL Tonsil hypertrophy (TH) HU CSA Computational Fluid-Particle Dynamics (CFPD) Aerosol deposition I-TH Pediatric airway HPLC III-TH MT II-TH TA CT 3D TH WSS ICS IV-TH
ISSN:	0378-5173, 1873-3476, 1873-3476
Online-Zugang:	Volltext
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