Use of Prothrombin Complex Concentrate in Patients during Heart Transplantation after Implantation of a Left Ventricular Mechanical Support System

Heart transplantation in patients after implantation of mechanical cardiac support devices entails an extremely high risk for perioperative bleeding. Recombinant activated coagulation factor VII is presently used to reduce the volume of bleeding in this patient group. There are parallel data on its...

Full description

Saved in:
Bibliographic Details
Published in:Obshchai͡a︡ reanimatologii͡a Vol. 8; no. 6; p. 58
Main Authors: Lomivorotov, V. V., Shmyrev, V. A., Deryagin, M. N., Efremov, S. M., Kornilov, I. A., Chernyavsky, A. M.
Format: Journal Article
Language:English
Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 20.12.2012
Subjects:
концентрат протромбинового комплекса
ортотопическая трансплантация сердца
рекомбинантный активированный vii фактор свертывания крови
устройство механической поддержки сердца
ISSN:1813-9779, 2411-7110
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Heart transplantation in patients after implantation of mechanical cardiac support devices entails an extremely high risk for perioperative bleeding. Recombinant activated coagulation factor VII is presently used to reduce the volume of bleeding in this patient group. There are parallel data on its administration-induced thromboembolic events in the literature. This paper describes a case of using a prothrombin complex concentrate in a patient during explantation of a left ventricular bypass system and subsequent orthotopic heart transplantation in the presence of significant hypocoagulation. At the end of a surgery, 1200 IU of the agent was used at a remaining bleeding rate of more than 1000 ml/hour. Within the first 24 hours after surgery, the rate of discharge drainage was less than 100 ml/hour. A control plain chest X-ray study revealed massive left-sided hydrothorax on day 2 postsurgery. The left pleural cavity was revised under thoracoscopic guidance and 1000 ml of blood clots were evacuated. Although the administration of prothrombin complex concentrate did not guard against re-intervention, its use seems a promising strategy in life-threatening bleedings in patients after explantation of mechanical cardiac support devices. Further multicenter investigations are required to determine the efficacy and safety of prothrom-bin complex concentration in cardiac surgery. Key words: Recombinant activated coagulation factor VII, prothrombin complex concentration, mechanical cardiac support device, orthotopic heart transplantation.
AbstractList Heart transplantation in patients after implantation of mechanical cardiac support devices entails an extremely high risk for perioperative bleeding. Recombinant activated coagulation factor VII is presently used to reduce the volume of bleeding in this patient group. There are parallel data on its administration-induced thromboembolic events in the literature. This paper describes a case of using a prothrombin complex concentrate in a patient during explantation of a left ventricular bypass system and subsequent orthotopic heart transplantation in the presence of significant hypocoagulation. At the end of a surgery, 1200 IU of the agent was used at a remaining bleeding rate of more than 1000 ml/hour. Within the first 24 hours after surgery, the rate of discharge drainage was less than 100 ml/hour. A control plain chest X-ray study revealed massive left-sided hydrothorax on day 2 postsurgery. The left pleural cavity was revised under thoracoscopic guidance and 1000 ml of blood clots were evacuated. Although the administration of prothrombin complex concentrate did not guard against re-intervention, its use seems a promising strategy in life-threatening bleedings in patients after explantation of mechanical cardiac support devices. Further multicenter investigations are required to determine the efficacy and safety of prothrom-bin complex concentration in cardiac surgery. Key words: Recombinant activated coagulation factor VII, prothrombin complex concentration, mechanical cardiac support device, orthotopic heart transplantation.
Author Efremov, S. M.
Lomivorotov, V. V.
Shmyrev, V. A.
Chernyavsky, A. M.
Kornilov, I. A.
Deryagin, M. N.
Author_xml – sequence: 1
  givenname: V. V.
  surname: Lomivorotov
  fullname: Lomivorotov, V. V.
– sequence: 2
  givenname: V. A.
  surname: Shmyrev
  fullname: Shmyrev, V. A.
– sequence: 3
  givenname: M. N.
  surname: Deryagin
  fullname: Deryagin, M. N.
– sequence: 4
  givenname: S. M.
  surname: Efremov
  fullname: Efremov, S. M.
– sequence: 5
  givenname: I. A.
  surname: Kornilov
  fullname: Kornilov, I. A.
– sequence: 6
  givenname: A. M.
  surname: Chernyavsky
  fullname: Chernyavsky, A. M.
BookMark eNpN0dlKxDAUBuAgCo7LG3iRF6hmaZrmUgaXgREFl9twkqZaaZOSZEBfwyc2M4p4dTh_wgeH_wjt--AdQmeUnFPBG3JBW8orJaWqGKGsairR7qEFqymtJKVkHy3-fhyi05TeCSFUSqF4u0Bfz8nh0OOHGPJbDJMZPF6GaR7dR5neOp8jZIdL_AB5KGvC3SYO_hXfOogZP0XwaR7B5_IcPIY-u4hX07-o8IDXrs_4ZcsNdjNCxHfOvoEfLIz4cTPPoViPnym76QQd9DAmd_o7j9Hz9dXT8rZa39-slpfrylIh20pw2SlmqSE16ahkhgpGFHRWkIYpUjPXmI6y2ioCoEzPjHTQGKY4t0wYxY_R6sftArzrOQ4TxE8dYNC7IMRXXQ4c7Og0kbJ1TQFbWUBWG2EM57xrOtlLJaFY9Y9lY0gpuv7Po0TvatLbEvS2BL2tSTdatPwb5s6JSA
ContentType Journal Article
DBID AAYXX
CITATION
DOA
DOI 10.15360/1813-9779-2012-6-58
DatabaseName CrossRef
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Open Access Full Text
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
EISSN 2411-7110
ExternalDocumentID oai_doaj_org_article_0778e6e6b8724c24b5bb333d6d7f797a
10_15360_1813_9779_2012_6_58
GroupedDBID 642
AAYXX
ADBBV
ALMA_UNASSIGNED_HOLDINGS
BCNDV
CITATION
GROUPED_DOAJ
IPNFZ
OK1
RIG
ID FETCH-LOGICAL-c1578-537d92c1b040d172b15209adc50629042e6bd124c90aa9bf2b7ea6b2933c25b93
IEDL.DBID DOA
ISSN 1813-9779
IngestDate Fri Oct 03 12:51:00 EDT 2025
Sat Nov 29 03:15:27 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c1578-537d92c1b040d172b15209adc50629042e6bd124c90aa9bf2b7ea6b2933c25b93
OpenAccessLink https://doaj.org/article/0778e6e6b8724c24b5bb333d6d7f797a
ParticipantIDs doaj_primary_oai_doaj_org_article_0778e6e6b8724c24b5bb333d6d7f797a
crossref_primary_10_15360_1813_9779_2012_6_58
PublicationCentury 2000
PublicationDate 2012-12-20
PublicationDateYYYYMMDD 2012-12-20
PublicationDate_xml – month: 12
  year: 2012
  text: 2012-12-20
  day: 20
PublicationDecade 2010
PublicationTitle Obshchai͡a︡ reanimatologii͡a
PublicationYear 2012
Publisher Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
Publisher_xml – name: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
SSID ssj0001775938
Score 1.8240288
Snippet Heart transplantation in patients after implantation of mechanical cardiac support devices entails an extremely high risk for perioperative bleeding....
SourceID doaj
crossref
SourceType Open Website
Index Database
StartPage 58
SubjectTerms концентрат протромбинового комплекса
ортотопическая трансплантация сердца
рекомбинантный активированный vii фактор свертывания крови
устройство механической поддержки сердца
Title Use of Prothrombin Complex Concentrate in Patients during Heart Transplantation after Implantation of a Left Ventricular Mechanical Support System
URI https://doaj.org/article/0778e6e6b8724c24b5bb333d6d7f797a
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Open Access Full Text
  customDbUrl:
  eissn: 2411-7110
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0001775938
  issn: 1813-9779
  databaseCode: DOA
  dateStart: 20050101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LSiwxEA0iLtyIFxVfV7JwG-xOuvNYei-KC5VZqLgLeYKgPTLTit_hF1uVjMPs3AgNDUUTmpMq6qS76hQhp6mTqEKSmfbcsQ5yLNNZQLj3QvrOAGkuf_AfrtXtrX58NJOVUV9YE1blgStwZ41SOskkvVa8C7zzvfdCiCijysqoQo2A9awcpsrXFaV6U8ZYQwYTDEiOWfTNwTs0Z0sjOEnLmWQ48X0lL63I95c8c7lNthYEkZ7XF_tD1tKwQz7v54lOM53MpjjX4AWOsxQj-Tl9wH2oFZZjomCeVKHUOa0NiPQKXHmkVcP82dVGo4GW0eAUpYGXJlje0euUR_qAyz2VAlV6k7A1GHeS4gBQIOu0ipzvkvvLi7v_V2wxTYGFFsKS9UJFw0PrIWwj0BbfYgWMi6FvJDcQu4BxhGwfTOOc8Zl7lZz0QAdE4L03Yo-sD9Mh7RMakxZR6cbAZnRZaxdbF5QIvclAAVw-IOwbS_taRTMsHjYQe4vYW8TeIvZW2l4fkH8I-PJZlLwuBnAEu3AE-5MjHP7GIkdks3gEXLw5Juvj7C39JRvhfXyaz06Kj30BZbHTng
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Use+of+Prothrombin+Complex+Concentrate+in+Patients+during+Heart+Transplantation+after+Implantation+of+a+Left+Ventricular+Mechanical+Support+System&rft.jtitle=Obshchai%CD%A1a%EF%B8%A1+reanimatologii%CD%A1a&rft.au=V.+V.+Lomivorotov&rft.au=V.+A.+Shmyrev&rft.au=M.+N.+Deryagin&rft.au=S.+M.+Efremov&rft.date=2012-12-20&rft.pub=Federal+Research+and+Clinical+Center+of+Intensive+Care+Medicine+and+Rehabilitology%2C+Moscow%2C+Russia&rft.issn=1813-9779&rft.eissn=2411-7110&rft.volume=8&rft.issue=6&rft_id=info:doi/10.15360%2F1813-9779-2012-6-58&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_0778e6e6b8724c24b5bb333d6d7f797a
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1813-9779&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1813-9779&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1813-9779&client=summon