ALL-144: Oncogenic Deregulation of BCL11B in Lineage Ambiguous Leukemia

Acute leukemias of ambiguous lineage (ALAL) pose significant diagnostic and therapeutic challenges due to lack of clarity surrounding their cellular origins and driving genomic alterations, as well as poor long-term response to conventional chemotherapy. Most ALAL cases are diagnosed as mixed phenot...

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Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia Jg. 21; S. S269 - S270
Hauptverfasser:	Montefiori, Lindsey E., Bendig, Sonja, Gu, Zhaohui, Chen, Xiaolong, Polonen, Petri, Ma, Xiaotu, Murison, Alex, Zeng, Andy, Garcia-Prat, Laura, Dickerson, Kirsten, Iacobucci, Ilaria, Abdelhamed, Sherif, Hiltenbrand, Ryan, Mead, Paul E., Mehr, Cyrus M., Xu, Beisi, Cheng, Zhongshan, Chang, Ti-Cheng, Westover, Tamara, Ma, Jing, Stengel, Anna, Kimura, Shunsuke, Qu, Chunxu, Valentine, Marcus B., Rashkovan, Marissa, Luger, Selina, Litzow, Mark R., Rowe, Jacob M., den Boer, Monique L., Wang, Victoria, Yin, Jun, Kornblau, Steven M., Hunger, Stephen P., Loh, Mignon L., Pui, Ching-Hon, Yang, Wenjian, Crews, Kristine R., Roberts, Kathryn G., Yang, Jun J., Relling, Mary V., Evans, William E., Stock, Wendy, Paietta, Elisabeth M., Ferrando, Adolfo A., Zhang, Jinghui, Kern, Wolfgang, Haferlach, Torsten, Wu, Gang, Dick, John E., Klco, Jeffery M., Haferlach, Claudia, Mullighan, Charles G.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Elsevier Inc 01.09.2021
Schlagworte:	ALL BCL11B enhancer hijacking ETP-ALL lineage ambiguous MPAL ALL lineage ambiguous MPAL enhancer hijacking BCL11B ETP-ALL
ISSN:	2152-2650, 2152-2669
Online-Zugang:	Volltext
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