Dissection of the structure-function relationship of Na v channels

Voltage-gated sodium channels (Na ) undergo conformational shifts in response to membrane potential changes, a mechanism known as the electromechanical coupling. To delineate the structure-function relationship of human Na channels, we have performed systematic structural analysis using human Na 1.7...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 121; číslo 9; s. e2322899121
Hlavní autori:	Li, Zhangqiang, Wu, Qiurong, Huang, Gaoxingyu, Jin, Xueqin, Li, Jiaao, Pan, Xiaojing, Yan, Nieng
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 27.02.2024
Predmet:	Humans Membrane Potentials Mutation Structure-Activity Relationship Voltage-Gated Sodium Channels - genetics structure–function relationship electromechanical coupling voltage-gated sodium channel closed-state inactivation cryo-EM
ISSN:	1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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