Dissection of the structure-function relationship of Na v channels

Voltage-gated sodium channels (Na ) undergo conformational shifts in response to membrane potential changes, a mechanism known as the electromechanical coupling. To delineate the structure-function relationship of human Na channels, we have performed systematic structural analysis using human Na 1.7...

Full description

Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 9; p. e2322899121
Main Authors:	Li, Zhangqiang, Wu, Qiurong, Huang, Gaoxingyu, Jin, Xueqin, Li, Jiaao, Pan, Xiaojing, Yan, Nieng
Format:	Journal Article
Language:	English
Published:	United States 27.02.2024
Subjects:	Humans Membrane Potentials Mutation Structure-Activity Relationship Voltage-Gated Sodium Channels - genetics structure–function relationship electromechanical coupling voltage-gated sodium channel closed-state inactivation cryo-EM
ISSN:	1091-6490
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!