Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin

BACKGROUND Two-sample Mendelian randomization (2SMR) is a powerful tool for causal hypothesis testing. However, the simplicity of the statistical techniques combined with lack of causal inference reasoning has prompted an explosion of 2SMR studies, flooding scientific literature with findings that a...

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Bibliographic Details

Published in:	Epidemiology, biostatistics, and public health
Main Authors:	Foco, Luisa, De Bortoli, Marzia, Del Greco, M Fabiola, Frommelt Laura Sophie, Laura Sophie, Volani, Chiara, Riekschnitz, Diana Anna, Motta, Benedetta Maria, Fuchsberger, Christian, Völker, Uwe, Gögele, Martin, Dörr, Marcus, Teumer, Alexander, Pramstaller, Peter Paul, Rossini, Alessandra, Pattaro, Cristian
Format:	Journal Article
Language:	English
Published:	Milano University Press 08.09.2025
ISSN:	2282-0930, 2282-0930
Online Access:	Get full text
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