Prognostic significance of beat-to-beat variability of spatial heterogeneity of repolarisation analysed from 5-minute resting electrocardiogram in coronary artery disease
Abstract Background Data on the prognostic significance of temporal variability of spatial heterogeneity of electrocardiographic repolarisation in coronary artery disease (CAD) are limited. Purpose To evaluate the prognostic value of temporal variability of T-wave morphology analysed from 5-minute r...
Uložené v:
| Vydané v: | Europace (London, England) Ročník 26; číslo Supplement_1 |
|---|---|
| Hlavní autori: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
US
Oxford University Press
24.05.2024
|
| ISSN: | 1099-5129, 1532-2092 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Abstract
Background
Data on the prognostic significance of temporal variability of spatial heterogeneity of electrocardiographic repolarisation in coronary artery disease (CAD) are limited.
Purpose
To evaluate the prognostic value of temporal variability of T-wave morphology analysed from 5-minute resting ECG in CAD.
Methods
The standard deviation (SD) of T-wave morphology dispersion (TMD-SD), the SD of T-wave heterogeneity (TWH-SD), and the SD of total cosine R-to-T (TCRT-SD) were analysed on beat-to-beat basis from a 5-minute period of resting 12-lead ECG obtained before a clinical stress test in 1702 patients with angiographically verified CAD and well-preserved left ventricular function.
Results
During an average of 8.7±2.2 years of follow-up, 60 (3.5 %) patients experienced sudden cardiac death (SCD) or were resuscitated from a sudden cardiac arrest (SCA), 69 (4.1 %) patients experienced non-sudden cardiac death (NSCD), and 161 (9.5 %) patients died due to non-cardiac death (NCD). TMD-SD was significantly higher in patients who experienced SCD/SCA compared with those without such an event (1.72 ± 2.00 vs. 1.12 ± 1.75, p= 0.01, respectively) and in patients who succumbed to NSCD compared with those without such an event (1.57 ± 1.74 vs. 1.12 ± 1.76, p=0.04, respectively), but did not differ significantly between patients who experienced NCD and those without such an event (1.16 ± 1.42 vs. 1.14 ± 1.79, p=0.86, respectively). After adjusting for relevant clinical risk factors in the Cox multivariate hazards model, TMD-SD retained its significant association with the risk of SCD/SCA (HR 1.119, 95 % CIs 1.015–1.233, p=0.024), but not with the risk of NSCD (HR 1.089, 95 % CIs 0.983–1.206, p=0.103).
Conclusion
TMD-SD, representing temporal variability of spatial heterogeneity of electrocardiographic repolarisation, is independently associated with the long-term risk of SCD/SCA in CAD patients with well-preserved left ventricular function. |
|---|---|
| AbstractList | Abstract
Background
Data on the prognostic significance of temporal variability of spatial heterogeneity of electrocardiographic repolarisation in coronary artery disease (CAD) are limited.
Purpose
To evaluate the prognostic value of temporal variability of T-wave morphology analysed from 5-minute resting ECG in CAD.
Methods
The standard deviation (SD) of T-wave morphology dispersion (TMD-SD), the SD of T-wave heterogeneity (TWH-SD), and the SD of total cosine R-to-T (TCRT-SD) were analysed on beat-to-beat basis from a 5-minute period of resting 12-lead ECG obtained before a clinical stress test in 1702 patients with angiographically verified CAD and well-preserved left ventricular function.
Results
During an average of 8.7±2.2 years of follow-up, 60 (3.5 %) patients experienced sudden cardiac death (SCD) or were resuscitated from a sudden cardiac arrest (SCA), 69 (4.1 %) patients experienced non-sudden cardiac death (NSCD), and 161 (9.5 %) patients died due to non-cardiac death (NCD). TMD-SD was significantly higher in patients who experienced SCD/SCA compared with those without such an event (1.72 ± 2.00 vs. 1.12 ± 1.75, p= 0.01, respectively) and in patients who succumbed to NSCD compared with those without such an event (1.57 ± 1.74 vs. 1.12 ± 1.76, p=0.04, respectively), but did not differ significantly between patients who experienced NCD and those without such an event (1.16 ± 1.42 vs. 1.14 ± 1.79, p=0.86, respectively). After adjusting for relevant clinical risk factors in the Cox multivariate hazards model, TMD-SD retained its significant association with the risk of SCD/SCA (HR 1.119, 95 % CIs 1.015–1.233, p=0.024), but not with the risk of NSCD (HR 1.089, 95 % CIs 0.983–1.206, p=0.103).
Conclusion
TMD-SD, representing temporal variability of spatial heterogeneity of electrocardiographic repolarisation, is independently associated with the long-term risk of SCD/SCA in CAD patients with well-preserved left ventricular function. |
| Author | Huikuri, H V Ukkola, O H Junttila, M J Perkiomaki, J Kentta, T V Rahola, J T Kiviniemi, A M Tulppo, M P Mattila, S M |
| Author_xml | – sequence: 1 givenname: J surname: Perkiomaki fullname: Perkiomaki, J email: juha.perkiomaki@oulu.fi – sequence: 2 givenname: J T surname: Rahola fullname: Rahola, J T – sequence: 3 givenname: S M surname: Mattila fullname: Mattila, S M – sequence: 4 givenname: A M surname: Kiviniemi fullname: Kiviniemi, A M – sequence: 5 givenname: O H surname: Ukkola fullname: Ukkola, O H – sequence: 6 givenname: M P surname: Tulppo fullname: Tulppo, M P – sequence: 7 givenname: M J surname: Junttila fullname: Junttila, M J – sequence: 8 givenname: H V surname: Huikuri fullname: Huikuri, H V – sequence: 9 givenname: T V surname: Kentta fullname: Kentta, T V |
| BookMark | eNqNkE1OwzAQhS1UJNrCDVj4Am7HSZPGS1TxJyHBAtbRxBkHo9SO7BQpV-KUuGrZs5rRvHlvRt-CzZx3xNithJUEla_pEPyAmlKDJCFb5VBesLks8kxkoLJZ6kEpUchMXbFFjF8AsM1UMWc_b8F3zsfRah5t56yxGp0m7g1vCEcxenGs_BuDxcb2dpyOWhxwtNjzTxopJZCjsxBo8H3ajUn3jqPDforUchP8nhdib91hpLSVLrqOU096DF5jaK3vAu65dVz74B2GiWNI4RNvbSSMdM0uDfaRbs51yT4e7t93T-Ll9fF5d_citMxlKVrIld4a1RqFRVNVCo1UkJdZiUqlEWhQslG42RQNlAaIEiZoSlUBVrqs8iXbnHJ18DEGMvUQ7D79U0uoj7zrP971mXedeCfb-mTzh-F_jl8sVo7J |
| ContentType | Journal Article |
| Copyright | The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. 2024 |
| Copyright_xml | – notice: The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. 2024 |
| DBID | TOX AAYXX CITATION |
| DOI | 10.1093/europace/euae102.306 |
| DatabaseName | Oxford Journals Open Access Collection CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: TOX name: Oxford Journals Open Access Collection url: https://academic.oup.com/journals/ sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | EHRA 2024 7–9 April 2024 Berlin, Germany Abstract Supplement |
| EISSN | 1532-2092 |
| ExternalDocumentID | 10_1093_europace_euae102_306 10.1093/europace/euae102.306 |
| GroupedDBID | --- --K .2P .I3 .XZ .ZR 0R~ 1B1 1TH 29G 2WC 4.4 48X 53G 5GY 5VS 5WA 6PF 70D AABZA AACZT AAJKP AAJQQ AAMVS AAOGV AAPNW AAPQZ AAPXW AAUAY AAUQX AAVAP AAWTL ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABNHQ ABNKS ABPQP ABPTD ABQLI ABVGC ABWST ABXVV ABZBJ ACGFS ACPRK ACUFI ACUTO ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADOCK ADRTK ADVEK ADYVW ADZXQ AEGPL AEJOX AEKSI AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFXAL AGINJ AGKEF AGQXC AGSYK AGUTN AHMBA AHXPO AIJHB AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX AMNDL APIBT APWMN AXUDD BAWUL BAYMD BEYMZ BHONS BTRTY BVRKM C1A CAG CDBKE COF CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBD EBS EE~ EJD EMOBN ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HZ~ IHE IOX J21 JXSIZ KBUDW KOP KQ8 KSI KSN M-Z M41 MHKGH N9A NGC NOMLY NOYVH NQ- NTWIH NU- O0~ O9- OAUYM OAWHX ODMLO OJQWA OJZSN OK1 OPAEJ OVD P2P PAFKI PEELM PQQKQ Q1. Q5Y RD5 RIG ROL RPM RPZ RUSNO RW1 RXO SEL SV3 TCURE TEORI TJX TOX TR2 UHS VVN W8F WOQ X7H YAYTL YKOAZ YXANX ZKX ~91 AAYXX CITATION ROX |
| ID | FETCH-LOGICAL-c1316-d039c7f9df9a5b889af1903626a999a50c091b9a445b06f0ee5320b6980a8c683 |
| IEDL.DBID | TOX |
| ISSN | 1099-5129 |
| IngestDate | Sat Nov 29 05:19:28 EST 2025 Mon Jun 30 08:34:50 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | Supplement_1 |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. https://creativecommons.org/licenses/by-nc/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c1316-d039c7f9df9a5b889af1903626a999a50c091b9a445b06f0ee5320b6980a8c683 |
| OpenAccessLink | https://dx.doi.org/10.1093/europace/euae102.306 |
| ParticipantIDs | crossref_primary_10_1093_europace_euae102_306 oup_primary_10_1093_europace_euae102_306 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-05-24 |
| PublicationDateYYYYMMDD | 2024-05-24 |
| PublicationDate_xml | – month: 05 year: 2024 text: 2024-05-24 day: 24 |
| PublicationDecade | 2020 |
| PublicationPlace | US |
| PublicationPlace_xml | – name: US |
| PublicationTitle | Europace (London, England) |
| PublicationYear | 2024 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| SSID | ssj0007295 |
| Score | 2.3989215 |
| Snippet | Abstract
Background
Data on the prognostic significance of temporal variability of spatial heterogeneity of electrocardiographic repolarisation in coronary... |
| SourceID | crossref oup |
| SourceType | Index Database Publisher |
| Title | Prognostic significance of beat-to-beat variability of spatial heterogeneity of repolarisation analysed from 5-minute resting electrocardiogram in coronary artery disease |
| Volume | 26 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVASL databaseName: Oxford Journals Open Access Collection customDbUrl: eissn: 1532-2092 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007295 issn: 1099-5129 databaseCode: TOX dateStart: 19990101 isFulltext: true titleUrlDefault: https://academic.oup.com/journals/ providerName: Oxford University Press |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8NAEF5KEW--xYrKHjx4WZs02WT3KGLxoLWHCr2FfWJBE2nTQv-Sv9KZPEQFoZ6ysMsS-IaZWeabbwi5DL3XoTApU5FNGDg8zmQSAyCp49agoFktkvSQjkZiOpXjDum3vTC_S_gy6qNIBbwfHSyUg3h4HVUS2yEXaNeTp-mX54VEkVfVTSkZBrK2Ve6PS36EImxv-xZZhrv__qc9stMkkfSmRn2fdFx-QLYfmzL5IfkYzwsk0ME2RYIG0oEQXVp4qsH5srJg-KUreCnXQt1r3FsgvRoufkGOTAGm5ZoNrCy84rjCCkeqKiUTZyk2p1DO3mb5snQUx3xAJKTNaB1TUV2R_UVnOTUolaDma1qRSNe0qQwdkefh3eT2njVDGZgJozBhNoikSb20XiquhZDKQ06BojYKck3FAwMZiJYqjrkOEh84h6MndCJFoIRJRHRMunmRuxNCrU-QYQsZ0SCIdWKFtToA2_FW8oHWaY-wFp_svdbeyOqaeZS1AGQNABkA0CNXAOJGR083P3pGuuV86c7JllmVs8X8orK5TzrN3is |
| linkProvider | Oxford University Press |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prognostic+significance+of+beat-to-beat+variability+of+spatial+heterogeneity+of+repolarisation+analysed+from+5-minute+resting+electrocardiogram+in+coronary+artery+disease&rft.jtitle=Europace+%28London%2C+England%29&rft.au=Perkiomaki%2C+J&rft.au=Rahola%2C+J+T&rft.au=Mattila%2C+S+M&rft.au=Kiviniemi%2C+A+M&rft.date=2024-05-24&rft.issn=1099-5129&rft.eissn=1532-2092&rft.volume=26&rft.issue=Supplement_1&rft_id=info:doi/10.1093%2Feuropace%2Feuae102.306&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_europace_euae102_306 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1099-5129&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1099-5129&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1099-5129&client=summon |