Optical coherence tomography angiography in retinitis pigmentosa

Purpose The aim of this study is to describe macular vascular abnormalities in patients affected by retinitis pigmentosa using Optical coherence tomography angiography (OCT‐A). Methods Patients with a clinical diagnosis of retinitis pigmentosa underwent 3 × 3 Swept Source OCT‐A scans using a Swept‐S...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta ophthalmologica (Oxford, England) Jg. 95; H. S259
Hauptverfasser: Hassairi, A., Falfoul, Y., Matri, K., Ben Lassoued, O., Chebil, A., El Matri, L.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Malden Wiley Subscription Services, Inc 01.09.2017
Schlagworte:
Acuity
Angiography
Cysts
Edema
Ischemia
Medical imaging
Retina
Retinitis
Retinitis pigmentosa
Tomography
Visual perception
ISSN:1755-375X, 1755-3768
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Purpose The aim of this study is to describe macular vascular abnormalities in patients affected by retinitis pigmentosa using Optical coherence tomography angiography (OCT‐A). Methods Patients with a clinical diagnosis of retinitis pigmentosa underwent 3 × 3 Swept Source OCT‐A scans using a Swept‐Source DRI OCT Triton (Topcon Corporation, Japan). Scans with artifacts were excluded. Retinal vascular supply was estimated at the level of the superficial (SCP) and deep (DCP) capillary plexus, choriocapillaris and choroid. Results Six patients (12 eyes) were included in this study. Five were females (83.33%) and the mean age was 28.66 years. Mean best corrected visual acuity was 0.5 ± 0.3 LogMAR. Two patients presented bilateral macular edema on Swept Source‐OCT and showed focal dislocations in the vascular network at the level of the DCP on the OCT‐A, corresponding to the serous intraretinal cysts displacing the vascular plexus and the neural tissue. Qualitative analysis of OCT‐A at the macular area revealed a reduction of vessel density in the SCP and DCP. The DCP and especially the temporal area are more affected. Three patients (50%) showed an enlarged foveal avascular zone at the DCP level. Conclusions Using OCT‐A, we have demonstrated reduction of vessel densities especially located in the DCP. This vascular depletion could be an early event in the disease, which eventually causes ischemia, tissue loss and affects the macular function. Morphological vascular evaluation in patients affected by retinitis pigmentosa allows better understanding the pathogenesis of this disease and can have direct therapeutic implications for the future practical management of retinal dystrophies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2017.0F015