Evaluation of the G C S-Pupils Score for PrOgnosis in trauMatic brAin injury- The COMA Study

Glasgow Coma Scale-Pupils (GCS-P) score has been found to be strongly related to in-hospital mortality in retrospective studies. We hypothesized that GCS-P would be better prognosticator than Glasgow Coma Scale (GCS) in patients with traumatic brain injury (TBI). In this prospective, multicentric, o...

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Vydáno v:Brain injury Ročník 37; číslo 9; s. 1041 - 1047
Hlavní autoři: Mahajan, Charu, Sengupta, Deep, Kapoor, Indu, Prabhakar, Hemanshu, Kumar, Vijay, Purohit, Shobha, Priya, Vansh, Srivastava, Shashi, Thakur, Deepali, Karnik, Hemangi, Sati, Hem Chandra, Kalaivani, Mani
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 29.07.2023
Témata:
Glasgow Coma Scale-Pupils (GCS-P) score
Glasgow Coma Scale score
Traumatic brain injury
prognosis
outcome
ISSN:0269-9052, 1362-301X
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Shrnutí:Glasgow Coma Scale-Pupils (GCS-P) score has been found to be strongly related to in-hospital mortality in retrospective studies. We hypothesized that GCS-P would be better prognosticator than Glasgow Coma Scale (GCS) in patients with traumatic brain injury (TBI). In this prospective, multicentric, observational study, GCS and GCS-P scores were noted in adult TBI patients at ICU admission. Demographic variables, relevant clinical history, clinical/radiological findings and ICU complications were also noted. Extended Glasgow Outcome scale was noted at hospital discharge and at 6 months post-injury. Logistic regression analysis was carried out to estimate the odds for poor outcome adjusted for covariates. Sensitivity, specificity, area under curve (AUC) and odds ratio are reported for poor outcome at estimated cutoff point. A total of 573 patients were included in this study. The predictive power for mortality, shown by the AUC, was 0.81 [95% CI: 0.77-0.85] for GCS and 0.81 [95% CI: 0.77-0.86] for GCS-P score, both being comparable. Similarly, the predictive ability for outcome at discharge and 6 months, the AUC-ROC for both GCS and GCS-P were comparable. GCS-P is a good predictor of mortality and poor outcome. However, the predictive performance of GCS and GCS-P for in-hospital mortality and functional outcome at discharge and at 6 months remains comparable.
ISSN:0269-9052
1362-301X
DOI:10.1080/02699052.2023.2227943