Explainable End-to-End Seizure Prediction via Stationary Wavelet Transform-Driven Dynamic Multiscale Fuzzy Clustering

Epileptic seizure prediction holds critical clinical significance for enhancing the quality of life in patients. Despite technological advances, existing approaches face persistent challenges arising from inter-subject variability in electroencephalogram (EEG) dynamics and the complex spatiotemporal...

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Vydané v:IEEE journal of biomedical and health informatics Ročník PP; s. 1 - 15
Hlavní autori: Wang, Jie, Wang, Yingchao, Nie, Weiwei, Yuan, Qi
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States IEEE 19.11.2025
Predmet:
Adaptation models
Brain modeling
Contrastive learning
Discrete wavelet transforms
Electroencephalogram
Electroencephalography
Feature extraction
Geometric attention mechanism
Heuristic algorithms
Multiscale explainable framework
Predictive models
Riemannian manifold-based fuzzy clustering
Seizure prediction
Stationary wavelet transform
Time-frequency analysis
Transformers
Wavelet transforms
ISSN:2168-2194, 2168-2208, 2168-2208
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Shrnutí:Epileptic seizure prediction holds critical clinical significance for enhancing the quality of life in patients. Despite technological advances, existing approaches face persistent challenges arising from inter-subject variability in electroencephalogram (EEG) dynamics and the complex spatiotemporal coupling associated with ictal transitions. These issues compromise both feature discriminability and model explainability. To address these dual limitations, we propose a novel stationary wavelet transform (SWT)-driven dynamic multiscale fuzzy clustering (SD-MFC) framework, an explainable prediction pipeline that integrates EEG signal analysis with transparent clinical decision-making. Methodologically, the spectral-temporal decomposition of EEG signals via SWT is combined with a geometric attention mechanism to model cross-channel dependencies. To capture the dynamic nature of EEG signals, we develop a Riemannian manifold-based fuzzy clustering algorithm through covariance matrix optimization and time-variant manifold metrics. Hierarchical feature fusion is achieved through multiscale convolutional kernels within a three-layer convolutional network. Model training incorporates contrastive learning with a hybrid supervised/self-supervised strategy to enhance robustness. Notably, two explainability methods: a joint feature visualization strategy and an efficient feature ablation study, are proposed to bridge the adaptation gap between the "black-box" nature of deep learning models and the requirements of clinical diagnostic. Experimental results on both intracranial and extracranial datasets demonstrate that SD-MFC framework not only exhibits superior predictive performance but also maintains a low FPR, offering a feasible scheme for clinical application of EEG-based seizure prediction. The code has been available at https://github.com/JW-Image/SD-MFC.
Bibliografia:ObjectType-Article-1
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ISSN:2168-2194
2168-2208
2168-2208
DOI:10.1109/JBHI.2025.3633739