Total Hip or Knee Arthroplasty in Patients with a History of Native Joint Septic Arthritis: A Meta-analysis and Systematic Review of Risk Factors of Prosthetic Joint Infection
Background: Septic arthritis is a debilitating diagnosis, and many of these patients elect to undergo total knee arthroplasty (TKA) and total hip arthroplasty (THA). The purpose of this systematic review and meta-analysis is to assess the risk of prosthetic joint infection (PJI) in those who undergo...
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| Veröffentlicht in: | Clinics in orthopedic surgery Jg. 17; H. 6; S. 958 - 970 |
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| Sprache: | Englisch |
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대한정형외과학회
01.12.2025
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| ISSN: | 2005-291X, 2005-4408 |
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| Abstract | Background: Septic arthritis is a debilitating diagnosis, and many of these patients elect to undergo total knee arthroplasty (TKA) and total hip arthroplasty (THA). The purpose of this systematic review and meta-analysis is to assess the risk of prosthetic joint infection (PJI) in those who undergo primary TKA or THA with a history of septic joint arthritis. Secondarily, we will evaluate patientspecific or surgical factors that could increase the risk of primary arthroplasty failure.
Methods: A comprehensive search of PubMed, CINAHL Plus, Embase, and Scopus was performed. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for study selection, data extraction, and analysis.
From a total of 404 articles, 18 studies were selected for inclusion.
Results: Our final cohort consisted of 1,758 arthroplasties with Staphylococcus species (n = 375 cases, 40%) being the most common causative septic arthritis agent. Male sex (70.5% vs. 51.1%, p = 0.0003) and Gram-negative bacteria cause (11.6% vs. 6.0%, p = 0.02) were associated with an increased risk of PJI following arthroplasty. There was no association found between arthroplasty failure and increasing age or body mass index. There was no difference in PJI rates between 1- and 2-stage arthroplasty (10.9% vs. 10.8%; p = 0.47).
Conclusions: Male sex and resistant organism as causes of septic arthritis were associated with an increased risk of PJI in patients with a history of native septic arthritis. Single- and 2-stage procedures had similar success rates. Future studies should be larger and focus on long-term outcomes in these patients. KCI Citation Count: 0 |
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| AbstractList | Background: Septic arthritis is a debilitating diagnosis, and many of these patients elect to undergo total knee arthroplasty (TKA) and total hip arthroplasty (THA). The purpose of this systematic review and meta-analysis is to assess the risk of prosthetic joint infection (PJI) in those who undergo primary TKA or THA with a history of septic joint arthritis. Secondarily, we will evaluate patientspecific or surgical factors that could increase the risk of primary arthroplasty failure.
Methods: A comprehensive search of PubMed, CINAHL Plus, Embase, and Scopus was performed. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for study selection, data extraction, and analysis.
From a total of 404 articles, 18 studies were selected for inclusion.
Results: Our final cohort consisted of 1,758 arthroplasties with Staphylococcus species (n = 375 cases, 40%) being the most common causative septic arthritis agent. Male sex (70.5% vs. 51.1%, p = 0.0003) and Gram-negative bacteria cause (11.6% vs. 6.0%, p = 0.02) were associated with an increased risk of PJI following arthroplasty. There was no association found between arthroplasty failure and increasing age or body mass index. There was no difference in PJI rates between 1- and 2-stage arthroplasty (10.9% vs. 10.8%; p = 0.47).
Conclusions: Male sex and resistant organism as causes of septic arthritis were associated with an increased risk of PJI in patients with a history of native septic arthritis. Single- and 2-stage procedures had similar success rates. Future studies should be larger and focus on long-term outcomes in these patients. KCI Citation Count: 0 |
| Author | De, Chiranjit Lakpriya, Sathya Pierce, Todd P. Sanka, Sravan Kumar Oni, Tofunmi Tahir, Muhammad |
| Author_xml | – sequence: 1 givenname: Sravan Kumar orcidid: 0000-0002-5844-9666 surname: Sanka fullname: Sanka, Sravan Kumar organization: Department of Trauma and Orthopaedics, East Kent Hospitals University NHS Foundation Trust, Kent, UK – sequence: 2 givenname: Muhammad orcidid: 0000-0001-8836-7496 surname: Tahir fullname: Tahir, Muhammad organization: Department of Trauma and Orthopaedics, East Kent Hospitals University NHS Foundation Trust, Kent, UK – sequence: 3 givenname: Sathya orcidid: 0000-0003-1921-7560 surname: Lakpriya fullname: Lakpriya, Sathya organization: Department of Trauma and Orthopaedics, East Kent Hospitals University NHS Foundation Trust, Kent, UK – sequence: 4 givenname: Chiranjit orcidid: 0000-0002-9273-4022 surname: De fullname: De, Chiranjit organization: Department of Trauma and Orthopaedics, East Kent Hospitals University NHS Foundation Trust, Kent, UK – sequence: 5 givenname: Tofunmi orcidid: 0000-0003-0910-698X surname: Oni fullname: Oni, Tofunmi organization: Department of Trauma and Orthopaedics, East Kent Hospitals University NHS Foundation Trust, Kent, UK – sequence: 6 givenname: Todd P. orcidid: 0000-0001-9514-7360 surname: Pierce fullname: Pierce, Todd P. organization: University of Pittsburgh Medical Center Western Maryland, Cumberland, MD, USA |
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| Cites_doi | 10.1016/j.arth.2019.08.034 10.1016/j.arth.2014.01.013 10.1302/0301-620X.104B2.BJJ-2021-1209.R1 10.1111/os.12485 10.2106/JBJS.RVW.19.00059 10.5301/hipint.5000538 10.1186/s13018-020-02062-1 10.1016/j.arth.2020.09.020 10.2106/JBJS.20.01678 10.5194/jbji-7-81-2022 10.1016/j.arth.2020.02.065 10.1007/s00264-021-05013-5 10.1186/s12891-019-2652-7 10.1016/j.arth.2018.09.081 10.1016/j.arth.2019.05.040 10.1111/imj.12510 10.1097/CORR.0000000000000688 10.1016/j.arth.2022.03.011 10.1016/j.artd.2020.05.012 10.1186/s13018-019-1074-4 10.1016/j.jinf.2008.07.001 10.1007/s00402-024-05249-x 10.1007/s11999-014-3545-6 |
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