Acetaminophen Inhibits Fatty Infiltration without Impairing Tendon-Bone Interface Healing in a Rat Model of Acute Rotator Cuff Repair
Background: Rotator cuff (RC) tears are a common shoulder disorder associated with pain, dysfunction, and progressive muscle degeneration. Postoperative muscle atrophy and fatty infiltration are key factors contributing to poor healing outcomes, increased rerupture rates, and long-term functional im...
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| Published in: | Clinics in orthopedic surgery Vol. 17; no. 6; pp. 1015 - 1024 |
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| Format: | Journal Article |
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대한정형외과학회
01.12.2025
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| ISSN: | 2005-291X, 2005-4408 |
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| Abstract | Background: Rotator cuff (RC) tears are a common shoulder disorder associated with pain, dysfunction, and progressive muscle degeneration. Postoperative muscle atrophy and fatty infiltration are key factors contributing to poor healing outcomes, increased rerupture rates, and long-term functional impairment. While acetaminophen (APAP) is widely used for pain management, its potential effects on muscle fatty infiltration and tendon-bone interface (TBI) healing remain unclear. This study aimed to investigate whether APAP influences fatty infiltration and TBI healing after RC surgery. We hypothesized that APAP would reduce fatty infiltration by downregulating peroxisome proliferator-activated receptor gamma (PPAR-γ) while preserving histological and biomechanical TBI integrity.
Methods: A RC repair rat model was created using 12-week-old male Sprague-Dawley rats. Ten rats in the APAP group received an oral dose of 30 mg/kg APAP daily for 4 weeks after RC tendon transection, and 10 rats in the control group were administered only 0.9% saline. All rats were sacrificed 4 weeks after surgery. Fatty infiltration was analyzed qualitatively and quantitatively in the proximal part of the supraspinatus muscle. TBI was evaluated for RC healing effect through general tissue staining and biomechanical strength measurements.
Results: Four weeks after tendon repair, the APAP group showed significant prevention of supraspinatus fatty infiltration compared to the control group (p < 0.001). These results were confirmed through immunohistochemical results showing that PPAR-γ, a marker gene for fatty infiltration, was significantly decreased in the APAP group (p < 0.001). Histological healing assessments between the 2 groups were not significantly different (p = 0.634). Additionally, mechanical strength was not negatively affected.
Conclusions: APAP treatment was associated with prevention of supraspinatus fatty infiltration without adversely affecting TBI healing in an RC repair model. KCI Citation Count: 0 |
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| AbstractList | Background: Rotator cuff (RC) tears are a common shoulder disorder associated with pain, dysfunction, and progressive muscle degeneration. Postoperative muscle atrophy and fatty infiltration are key factors contributing to poor healing outcomes, increased rerupture rates, and long-term functional impairment. While acetaminophen (APAP) is widely used for pain management, its potential effects on muscle fatty infiltration and tendon-bone interface (TBI) healing remain unclear. This study aimed to investigate whether APAP influences fatty infiltration and TBI healing after RC surgery. We hypothesized that APAP would reduce fatty infiltration by downregulating peroxisome proliferator-activated receptor gamma (PPAR-γ) while preserving histological and biomechanical TBI integrity.
Methods: A RC repair rat model was created using 12-week-old male Sprague-Dawley rats. Ten rats in the APAP group received an oral dose of 30 mg/kg APAP daily for 4 weeks after RC tendon transection, and 10 rats in the control group were administered only 0.9% saline. All rats were sacrificed 4 weeks after surgery. Fatty infiltration was analyzed qualitatively and quantitatively in the proximal part of the supraspinatus muscle. TBI was evaluated for RC healing effect through general tissue staining and biomechanical strength measurements.
Results: Four weeks after tendon repair, the APAP group showed significant prevention of supraspinatus fatty infiltration compared to the control group (p < 0.001). These results were confirmed through immunohistochemical results showing that PPAR-γ, a marker gene for fatty infiltration, was significantly decreased in the APAP group (p < 0.001). Histological healing assessments between the 2 groups were not significantly different (p = 0.634). Additionally, mechanical strength was not negatively affected.
Conclusions: APAP treatment was associated with prevention of supraspinatus fatty infiltration without adversely affecting TBI healing in an RC repair model. KCI Citation Count: 0 |
| Author | Kim, Jun-Young Chung, Seok Won Cho, Chul-Hyun Yoon, Jong Pil Kim, Dong-Hyun Choi, Yoon Seong Lee, Hyun Joo Park, Sung-Jin |
| Author_xml | – sequence: 1 givenname: Jong Pil orcidid: 0000-0001-6446-6254 surname: Yoon fullname: Yoon, Jong Pil organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 2 givenname: Sung-Jin orcidid: 0009-0008-6869-0788 surname: Park fullname: Park, Sung-Jin organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 3 givenname: Dong-Hyun orcidid: 0000-0001-9078-5953 surname: Kim fullname: Kim, Dong-Hyun organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 4 givenname: Yoon Seong orcidid: 0009-0006-1483-0023 surname: Choi fullname: Choi, Yoon Seong organization: Department of Carbon Hybrid Fiber Science, Kyungpook National University, Daegu, Korea – sequence: 5 givenname: Hyun Joo orcidid: 0000-0003-2837-3434 surname: Lee fullname: Lee, Hyun Joo organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 6 givenname: Jun-Young orcidid: 0000-0003-4700-3041 surname: Kim fullname: Kim, Jun-Young organization: Department of Orthopedic Surgery, Daegu Catholic University School of Medicine, Daegu, Korea – sequence: 7 givenname: Chul-Hyun orcidid: 0000-0003-0252-8741 surname: Cho fullname: Cho, Chul-Hyun organization: Department of Orthopedic Surgery, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea – sequence: 8 givenname: Seok Won orcidid: 0000-0002-8221-9289 surname: Chung fullname: Chung, Seok Won organization: Department of Orthopedic Surgery, Konkuk University Medical Center, Seoul, Korea |
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| Title | Acetaminophen Inhibits Fatty Infiltration without Impairing Tendon-Bone Interface Healing in a Rat Model of Acute Rotator Cuff Repair |
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