Stable electron-irradiated [1- 13 C]alanine radicals for metabolic imaging with dynamic nuclear polarization

Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic resonance experiments by >10 4 -fold, permitting isotopically labeled molecules to be transiently visible in magnetic resonance imaging scans. dDNP mechanistically takes place at ~1 K and requires unpaired elect...

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Vydané v:	Science advances Ročník 11; číslo 47; s. eadz4334
Hlavní autori:	Rooney, Catriona H. E., Lau, Justin Y. C., Hansen, Esben S. S., Christensen, Nichlas Vous, Dang, Duy A., Petersson, Kristoffer, Tullis, Iain D. C., Vojnovic, Borivoj, Smart, Sean, Myers, William, Richardson, Zoe, Lewis, Jarrod, Kennedy, Brett W. C., Bowen, Alice M., Bertelsen, Lotte Bonde, Laustsen, Christoffer, Tyler, Damian J., Miller, Jack J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 21.11.2025
Predmet:	Alanine - chemistry Alanine - metabolism Animals Carbon Isotopes - chemistry Electrons Free Radicals - chemistry Kidney - diagnostic imaging Kidney - metabolism Magnetic Resonance Imaging - methods Rats
ISSN:	2375-2548, 2375-2548
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