Stable electron-irradiated [1- 13 C]alanine radicals for metabolic imaging with dynamic nuclear polarization

Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic resonance experiments by >10 4 -fold, permitting isotopically labeled molecules to be transiently visible in magnetic resonance imaging scans. dDNP mechanistically takes place at ~1 K and requires unpaired elect...

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Bibliographic Details

Published in:	Science advances Vol. 11; no. 47; p. eadz4334
Main Authors:	Rooney, Catriona H. E., Lau, Justin Y. C., Hansen, Esben S. S., Christensen, Nichlas Vous, Dang, Duy A., Petersson, Kristoffer, Tullis, Iain D. C., Vojnovic, Borivoj, Smart, Sean, Myers, William, Richardson, Zoe, Lewis, Jarrod, Kennedy, Brett W. C., Bowen, Alice M., Bertelsen, Lotte Bonde, Laustsen, Christoffer, Tyler, Damian J., Miller, Jack J.
Format:	Journal Article
Language:	English
Published:	United States 21.11.2025
Subjects:	Alanine - chemistry Alanine - metabolism Animals Carbon Isotopes - chemistry Electrons Free Radicals - chemistry Kidney - diagnostic imaging Kidney - metabolism Magnetic Resonance Imaging - methods Rats
ISSN:	2375-2548, 2375-2548
Online Access:	Get full text
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