Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp 3 ‐Rich Compounds With Distinct Phenotypic Effects

A ‘top down’ scaffold remodelling approach to library synthesis was applied to spirotricyclic ureas prepared by a complexity‐generating oxidative dearomatisation. Eighteen structurally‐distinct, sp 3 ‐rich scaffolds were accessed from the parent tricycle through ring addition, cleavage and expansion...

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Bibliographic Details

Published in:	Chemistry : a European journal Vol. 29; no. 26; p. e202203992
Main Authors:	Okolo, Ephraim A., Pahl, Axel, Sievers, Sonja, Pask, Christopher M., Nelson, Adam, Marsden, Stephen P.
Format:	Journal Article
Language:	English
Published:	Germany 08.05.2023
Subjects:	Gene Library Small Molecule Libraries - chemistry phenotypic screening library synthesis molecular diversity dearomatisation
ISSN:	0947-6539, 1521-3765
Online Access:	Get full text
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