The role of meibum proteins in the pathogenesis of meibomian gland dysfunction

Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provide...

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Bibliographic Details
Published in:Vestnik oftal'mologii Vol. 141; no. 1; p. 70
Main Authors: Safonova, T N, Zaitseva, G V
Format: Journal Article
Language:English
Russian
Published: Russia (Federation) 2025
Subjects:
Eye Proteins - metabolism
Humans
Meibomian Gland Dysfunction - etiology
Meibomian Gland Dysfunction - metabolism
Meibomian Gland Dysfunction - physiopathology
Meibomian Glands - metabolism
Meibomian Glands - physiopathology
Tears - chemistry
Tears - metabolism
meibomian gland dysfunction
meibomian glands
lactoferrin
lipocalin
meibum
keratins
proteomic analysis of meibum
ISSN:0042-465X
Online Access:Get more information
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Summary:Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality. The article also analyzes modern methods for studying meibomian gland secretion.
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ISSN:0042-465X
DOI:10.17116/oftalma202514101170