The role of meibum proteins in the pathogenesis of meibomian gland dysfunction

Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provide...

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Veröffentlicht in:Vestnik oftal'mologii Jg. 141; H. 1; S. 70
Hauptverfasser: Safonova, T N, Zaitseva, G V
Format: Journal Article
Sprache:Englisch
Russisch
Veröffentlicht: Russia (Federation) 2025
Schlagworte:
Eye Proteins - metabolism
Humans
Meibomian Gland Dysfunction - etiology
Meibomian Gland Dysfunction - metabolism
Meibomian Gland Dysfunction - physiopathology
Meibomian Glands - metabolism
Meibomian Glands - physiopathology
Tears - chemistry
Tears - metabolism
meibomian gland dysfunction
meibomian glands
lactoferrin
lipocalin
meibum
keratins
proteomic analysis of meibum
ISSN:0042-465X
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Zusammenfassung:Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality. The article also analyzes modern methods for studying meibomian gland secretion.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0042-465X
DOI:10.17116/oftalma202514101170