The role of meibum proteins in the pathogenesis of meibomian gland dysfunction

Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provide...

Full description

Saved in:
Bibliographic Details
Published in:Vestnik oftal'mologii Vol. 141; no. 1; p. 70
Main Authors: Safonova, T N, Zaitseva, G V
Format: Journal Article
Language:English
Russian
Published: Russia (Federation) 2025
Subjects:
Eye Proteins - metabolism
Humans
Meibomian Gland Dysfunction - etiology
Meibomian Gland Dysfunction - metabolism
Meibomian Gland Dysfunction - physiopathology
Meibomian Glands - metabolism
Meibomian Glands - physiopathology
Tears - chemistry
Tears - metabolism
meibomian gland dysfunction
meibomian glands
lactoferrin
lipocalin
meibum
keratins
proteomic analysis of meibum
ISSN:0042-465X
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality. The article also analyzes modern methods for studying meibomian gland secretion.
AbstractList Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality. The article also analyzes modern methods for studying meibomian gland secretion.Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality. The article also analyzes modern methods for studying meibomian gland secretion.
Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality. The article also analyzes modern methods for studying meibomian gland secretion.
Author Zaitseva, G V
Safonova, T N
Author_xml – sequence: 1
  givenname: T N
  orcidid: 0000-0002-4601-0904
  surname: Safonova
  fullname: Safonova, T N
  organization: Krasnov Research Institute of Eye Diseases, Moscow, Russia
– sequence: 2
  givenname: G V
  orcidid: 0000-0001-8575-3076
  surname: Zaitseva
  fullname: Zaitseva, G V
  organization: Krasnov Research Institute of Eye Diseases, Moscow, Russia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40047025$$D View this record in MEDLINE/PubMed
BookMark eNo1kDtPwzAURj0U0VL6DxDyyBLwTfwoI6p4SRUsRWKLbOemNYrtECdD_z2WaKc7nKNPR_eKzEIMSMgNsHtQAPIhtqPuvC5ZKYADA1BsRhaM8bLgUnzPySqlH8YYcCFByUsy5xmqrC_Ix-6AdIgd0thSj85MnvZDHNGFRF2gY8a9Hg9xjwGTS2cteqcD3Xc6NLQ5pnYKdnQxXJOLVncJV6e7JF8vz7vNW7H9fH3fPG0Lm_tEsS6NRaOEbJp1yyWWRkjWoMV15pUuIWOwQlTcyEorFJYrIzlWUppKZGFJ7v53c-vvhGmsvUsWu9yDcUp1BYpzCewRsnp7Uifjsan7wXk9HOvzD8o_nqBg7w
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.17116/oftalma202514101170
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
DocumentTitleAlternate Rol' belkov meibuma v patogeneze disfunktsii meibomievykh zhelez
ExternalDocumentID 40047025
Genre Journal Article
English Abstract
Review
GroupedDBID .GJ
53G
ALMA_UNASSIGNED_HOLDINGS
CGR
CUY
CVF
ECM
EIF
F5P
NPM
VCL
VIT
VME
7X8
ID FETCH-LOGICAL-c1015-82bceb756dd8f46e2b560dece8c103a21bce1c5534b63a7e5c47b64e366b353a2
IEDL.DBID 7X8
ISSN 0042-465X
IngestDate Thu Oct 02 11:10:14 EDT 2025
Tue May 13 01:31:26 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords meibomian gland dysfunction
meibomian glands
lactoferrin
lipocalin
meibum
keratins
proteomic analysis of meibum
Language English
Russian
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c1015-82bceb756dd8f46e2b560dece8c103a21bce1c5534b63a7e5c47b64e366b353a2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0001-8575-3076
0000-0002-4601-0904
PMID 40047025
PQID 3174461091
PQPubID 23479
ParticipantIDs proquest_miscellaneous_3174461091
pubmed_primary_40047025
PublicationCentury 2000
PublicationDate 2025-00-00
PublicationDateYYYYMMDD 2025-01-01
PublicationDate_xml – year: 2025
  text: 2025-00-00
PublicationDecade 2020
PublicationPlace Russia (Federation)
PublicationPlace_xml – name: Russia (Federation)
PublicationTitle Vestnik oftal'mologii
PublicationTitleAlternate Vestn Oftalmol
PublicationYear 2025
SSID ssj0001456176
Score 2.2996144
SecondaryResourceType review_article
Snippet Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 70
SubjectTerms Eye Proteins - metabolism
Humans
Meibomian Gland Dysfunction - etiology
Meibomian Gland Dysfunction - metabolism
Meibomian Gland Dysfunction - physiopathology
Meibomian Glands - metabolism
Meibomian Glands - physiopathology
Tears - chemistry
Tears - metabolism
Title The role of meibum proteins in the pathogenesis of meibomian gland dysfunction
URI https://www.ncbi.nlm.nih.gov/pubmed/40047025
https://www.proquest.com/docview/3174461091
Volume 141
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA7qevDiA1_riwhey9qmeexJRFw8aNmDSm-leVQKtl23ruC_dybtsidB8NJLEkgnk5kvk8l8hFwxFwFK4CYQTsEBRYwLJHLnAewkwZjTyvl33K-PMklUmo6nfcCt7dMqlzbRG2rbGIyRj8DPxb42eHgz-wiQNQpvV3sKjXUyYABlMKVLpmoVY0F04Pnl_CsUmEPav56TYShGYOfy9yqPEGbHIRZHu_4dZ3p_M9n570x3yXaPNOltpxp7ZG2-2CcJqAXFjELaFLRypV5U1JdqKOuWljUFOEiRpLh5QxtYtstuTQVqRD3fB7XfLXpDXNED8jK5f757CHpKhcDAD_JARdo4LbmwVhWxcJEGxGOdcQraWR6F0BwazlmsBcul4yaWWsSOCaEZhw6HZKNuandMqOQ2N47lIbc6toUbKxNpIZTEY68N-ZBcLsWTgcriPUReu2bRZisBDclRJ-Ns1tXWyNCkSFiQkz-MPiVbuHZdQOSMDArYsO6cbJqvz7KdX3hdgG8yffoBES--pw
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+role+of+meibum+proteins+in+the+pathogenesis+of+meibomian+gland+dysfunction&rft.jtitle=Vestnik+oftal%27mologii&rft.au=Safonova%2C+T+N&rft.au=Zaitseva%2C+G+V&rft.date=2025-01-01&rft.issn=0042-465X&rft.volume=141&rft.issue=1&rft.spage=70&rft_id=info:doi/10.17116%2Foftalma202514101170&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0042-465X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0042-465X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0042-465X&client=summon