Biomarkers in tear fluid in uveitis

The etiology of uveitis, choroid inflammation, is diverse, the disease is often recurrent, difficult to treat, and frequently results in disability at a young age. Studies investigating the tear fluid composition in uveitis have revealed promising biomarkers relevant for prognosis and treatment opti...

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Published in:Vestnik oftal'mologii Vol. 141; no. 4; p. 88
Main Authors: Chesnokova, N B, Katargina, L A, Pavlenko, T A, Beznos, O V
Format: Journal Article
Language:English
Russian
Published: Russia (Federation) 2025
Subjects:
Biomarkers - analysis
Biomarkers - metabolism
Eye Proteins - analysis
Eye Proteins - metabolism
Humans
Prognosis
Tears - chemistry
Tears - metabolism
Uveitis - diagnosis
Uveitis - metabolism
nitric oxide
tear fluid
antiproteases
cytokines
uveitis
antioxidant activity
proteome
ISSN:0042-465X
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Abstract The etiology of uveitis, choroid inflammation, is diverse, the disease is often recurrent, difficult to treat, and frequently results in disability at a young age. Studies investigating the tear fluid composition in uveitis have revealed promising biomarkers relevant for prognosis and treatment optimization. This review presents literature data on changes in the tear fluid content of proteins involved in local immune responses, intercellular interactions, proteolytic and free radical processes, nitric oxide metabolism, and other metabolic pathways in different forms of uveitis. The paper also demonstrates the significance of assessing these changes for prognosis and for a pathogenetically based, personalized treatment approach, and identifies specific alterations associated with different uveitis etiologies, offering insight into the mechanisms underlying this pathology.
AbstractList The etiology of uveitis, choroid inflammation, is diverse, the disease is often recurrent, difficult to treat, and frequently results in disability at a young age. Studies investigating the tear fluid composition in uveitis have revealed promising biomarkers relevant for prognosis and treatment optimization. This review presents literature data on changes in the tear fluid content of proteins involved in local immune responses, intercellular interactions, proteolytic and free radical processes, nitric oxide metabolism, and other metabolic pathways in different forms of uveitis. The paper also demonstrates the significance of assessing these changes for prognosis and for a pathogenetically based, personalized treatment approach, and identifies specific alterations associated with different uveitis etiologies, offering insight into the mechanisms underlying this pathology.
The etiology of uveitis, choroid inflammation, is diverse, the disease is often recurrent, difficult to treat, and frequently results in disability at a young age. Studies investigating the tear fluid composition in uveitis have revealed promising biomarkers relevant for prognosis and treatment optimization. This review presents literature data on changes in the tear fluid content of proteins involved in local immune responses, intercellular interactions, proteolytic and free radical processes, nitric oxide metabolism, and other metabolic pathways in different forms of uveitis. The paper also demonstrates the significance of assessing these changes for prognosis and for a pathogenetically based, personalized treatment approach, and identifies specific alterations associated with different uveitis etiologies, offering insight into the mechanisms underlying this pathology.The etiology of uveitis, choroid inflammation, is diverse, the disease is often recurrent, difficult to treat, and frequently results in disability at a young age. Studies investigating the tear fluid composition in uveitis have revealed promising biomarkers relevant for prognosis and treatment optimization. This review presents literature data on changes in the tear fluid content of proteins involved in local immune responses, intercellular interactions, proteolytic and free radical processes, nitric oxide metabolism, and other metabolic pathways in different forms of uveitis. The paper also demonstrates the significance of assessing these changes for prognosis and for a pathogenetically based, personalized treatment approach, and identifies specific alterations associated with different uveitis etiologies, offering insight into the mechanisms underlying this pathology.
Author Katargina, L A
Chesnokova, N B
Pavlenko, T A
Beznos, O V
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  surname: Beznos
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  organization: Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia
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tear fluid
antiproteases
cytokines
uveitis
antioxidant activity
proteome
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Russian
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SubjectTerms Biomarkers - analysis
Biomarkers - metabolism
Eye Proteins - analysis
Eye Proteins - metabolism
Humans
Prognosis
Tears - chemistry
Tears - metabolism
Uveitis - diagnosis
Uveitis - metabolism
Title Biomarkers in tear fluid in uveitis
URI https://www.ncbi.nlm.nih.gov/pubmed/40920163
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