Biomarkers in tear fluid in uveitis

The etiology of uveitis, choroid inflammation, is diverse, the disease is often recurrent, difficult to treat, and frequently results in disability at a young age. Studies investigating the tear fluid composition in uveitis have revealed promising biomarkers relevant for prognosis and treatment opti...

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Vydáno v:Vestnik oftal'mologii Ročník 141; číslo 4; s. 88
Hlavní autoři: Chesnokova, N B, Katargina, L A, Pavlenko, T A, Beznos, O V
Médium: Journal Article
Jazyk:angličtina
ruština
Vydáno: Russia (Federation) 2025
Témata:
Biomarkers - analysis
Biomarkers - metabolism
Eye Proteins - analysis
Eye Proteins - metabolism
Humans
Prognosis
Tears - chemistry
Tears - metabolism
Uveitis - diagnosis
Uveitis - metabolism
nitric oxide
tear fluid
antiproteases
cytokines
uveitis
antioxidant activity
proteome
ISSN:0042-465X
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Shrnutí:The etiology of uveitis, choroid inflammation, is diverse, the disease is often recurrent, difficult to treat, and frequently results in disability at a young age. Studies investigating the tear fluid composition in uveitis have revealed promising biomarkers relevant for prognosis and treatment optimization. This review presents literature data on changes in the tear fluid content of proteins involved in local immune responses, intercellular interactions, proteolytic and free radical processes, nitric oxide metabolism, and other metabolic pathways in different forms of uveitis. The paper also demonstrates the significance of assessing these changes for prognosis and for a pathogenetically based, personalized treatment approach, and identifies specific alterations associated with different uveitis etiologies, offering insight into the mechanisms underlying this pathology.
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ObjectType-Review-3
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ISSN:0042-465X
DOI:10.17116/oftalma202514104188