Uveal melanoma and its local inflammation - good or bad for the patient?

The 21st century is characterized by the study of the features of malignant tumor infiltration by cellular components of the immune system. While some findings suggest a favorable role of lymphoid infiltration in tumors and its positive impact on survival due to immune defense, the opposite is obser...

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Vydáno v:Vestnik oftal'mologii Ročník 141; číslo 1; s. 5
Hlavní autoři: Brovkina, A F, Kabardikova, L A, Shcherbakov, P A, Bure, I V, Mirzaev, K B
Médium: Journal Article
Jazyk:angličtina
ruština
Vydáno: Russia (Federation) 2025
Témata:
Adult
Aged
Eye Enucleation - methods
Female
Humans
Inflammation - diagnosis
Lymphocytes, Tumor-Infiltrating - immunology
Lymphocytes, Tumor-Infiltrating - pathology
Male
Melanoma - blood
Melanoma - diagnosis
Melanoma - immunology
Melanoma - pathology
Melanoma - surgery
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
Prognosis
Tumor Microenvironment - immunology
Uveal Melanoma
Uveal Neoplasms - blood
Uveal Neoplasms - diagnosis
Uveal Neoplasms - immunology
Uveal Neoplasms - pathology
Uveal Neoplasms - surgery
microRNA-155
lymphoid infiltration
biomarker
uveal melanoma
ISSN:0042-465X
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Popis
Shrnutí:The 21st century is characterized by the study of the features of malignant tumor infiltration by cellular components of the immune system. While some findings suggest a favorable role of lymphoid infiltration in tumors and its positive impact on survival due to immune defense, the opposite is observed in uveal melanoma (UM): lymphoid infiltration significantly worsens the patient's prognosis. Research on this topic is limited, with some studies confined to experimental models. This study investigated the correlation between microRNA-155 expression in the plasma of UM patients after primary enucleation and with pathomorphological inflammatory changes. Eighty-three patients with UM were examined, in 21 cases lymphoid infiltration of the primary tumor was detected, in 6 cases accompanied by a microenvironment. The degree of tumor infiltration with lymphocytes was estimated as a percentage of the total number of cells in the analyzed field, ranging from 1% to 25%. Real-time polymerase chain reaction was used to determine microRNA-155 expression in the plasma of all patients before and after enucleation, and its correlation with the level of lymphoid infiltration was analyzed. Postoperative follow-up lasted 6 to 53 months (mean 21.5±14.9 months). In two cases, in the presence of a tumor microenvironment, metastases to the liver were detected 6 and 10 months after enucleation. MicroRNA-155 levels in a volunteer group were used as the control baseline, set at 100% for clarity and convenience. MicroRNA-155 expression levels were higher in patients with lymphoid infiltration ( <0.05) and tended to increase with the degree of primary tumor infiltration ( <0.001), which in itself, with the appearance of a perifocal lymphoid environment, indicated a poor prognosis. Monitoring microRNA-155 expression levels in the plasma of UM patients may help predict occult metastasis prior to enucleation. This is not only crucial for clinical follow-up but may also play a significant role in the development of targeted therapies.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0042-465X
DOI:10.17116/oftalma20251410115