Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes

The cryo-electron microscopy structures of yeast nucleoplasmic pre-60S ribosomal particles give insight into the function of multiple assembly factors in ribosome biogenesis. Dissecting ribosomal biogenesis in the nucleus The ribosome is one of the largest macromolecular complexes in the eukarotic c...

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Bibliographic Details
Published in:	Nature (London) Vol. 534; no. 7605; pp. 133 - 137
Main Authors:	Wu, Shan, Tutuncuoglu, Beril, Yan, Kaige, Brown, Hailey, Zhang, Yixiao, Tan, Dan, Gamalinda, Michael, Yuan, Yi, Li, Zhifei, Jakovljevic, Jelena, Ma, Chengying, Lei, Jianlin, Dong, Meng-Qiu, Woolford, John L., Gao, Ning
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.06.2016 Nature Publishing Group
Subjects:	101/28 101/58 45/70 45/90 631/337/1910 631/337/574/1789 631/45/500 631/535/1258/1259 631/80/389/2052 Active Transport, Cell Nucleus Base Sequence Catalytic Domain Cell Nucleus - chemistry Cell Nucleus - metabolism Cell Nucleus - ultrastructure Cryoelectron Microscopy Cytological research Cytoplasm - metabolism DNA, Ribosomal Spacer - chemistry DNA, Ribosomal Spacer - genetics DNA, Ribosomal Spacer - metabolism DNA, Ribosomal Spacer - ultrastructure Genetic research GTP Phosphohydrolases - chemistry GTP Phosphohydrolases - metabolism GTP Phosphohydrolases - ultrastructure GTP-Binding Proteins - chemistry GTP-Binding Proteins - metabolism GTP-Binding Proteins - ultrastructure Humanities and Social Sciences letter Models, Molecular Molecular Sequence Data Molecular structure multidisciplinary Nuclear Proteins - chemistry Nuclear Proteins - metabolism Nuclear Proteins - ultrastructure Nucleolus organizer region Polypeptides Protein Binding Protein research Protein synthesis Proteins Ribonucleic acid Ribonucleoproteins - chemistry Ribonucleoproteins - metabolism Ribonucleoproteins - ultrastructure Ribosomal Proteins - chemistry Ribosomal Proteins - isolation & purification Ribosomal Proteins - metabolism Ribosomal Proteins - ultrastructure Ribosome Subunits, Large, Eukaryotic - chemistry Ribosome Subunits, Large, Eukaryotic - metabolism Ribosome Subunits, Large, Eukaryotic - ultrastructure Ribosomes RNA RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Fungal - ultrastructure RNA, Ribosomal - genetics RNA, Ribosomal - metabolism RNA, Ribosomal - ultrastructure Rotation Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - isolation & purification Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - ultrastructure Science Yeasts United States China
ISSN:	0028-0836, 1476-4687
Online Access:	Get full text
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