DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in their regenerative capacity. However, HSPC function has been mostly assessed using transplantation as...

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Veröffentlicht in:	bioRxiv
Hauptverfasser:	Urbanus, Jos, Cosgrove, Jason, Beltman, Joost, Elhanati, Yuval, De Andrade Moral, Rafael, Conrad, Cecile, Jeroen Van Heijst, Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P, Frisen, Jonas, Fre, Silvia, Walczak, Aleksandra, Mora, Thierry, Jacobs, Heinz, Shumacher, Ton, Perie, Leila
Format:	Paper Verlag
Sprache:	Englisch
Veröffentlicht:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 09.12.2022 Cold Spring Harbor Laboratory
Ausgabe:	1.1
Schlagworte:	Aging Bone marrow Cell lineage Hematopoietic stem cells Immune system Immunology Microenvironments Myeloid cells Myelopoiesis Progenitor cells Transcriptomics Transplantation
ISSN:	2692-8205, 2692-8205
Online-Zugang:	Volltext
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