Characterization of the impact of daclizumab beta on circulating natural killer cells by mass cytometry

Daclizumab beta is a humanized monoclonal antibody that binds to CD25 and selectively inhibits high-affinity IL-2 receptor signaling. As a former treatment for relapsing forms of multiple sclerosis (RMS), daclizumab beta induces robust expansion of the CD56bright subpopulation of NK cells that is co...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Ranganath, Thanmayi, Simpson, Laura Jane, Seiler, Christof, Ferreira, Anne-Maud, Vendrame, Elena, Zhao, Nancy Q, Fontenot, Jason D, Holmes, Susan P, Blish, Catherine A
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 05.12.2019 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	CD25 antigen CD56 antigen CD57 antigen Cytometry Histocompatibility antigen HLA Immunology Immunomodulation Interleukin 2 Interleukin 2 receptors Lymphocytes T Monoclonal antibodies Multiple sclerosis Natural killer cells NKG2 antigen Perforin Phenotypes
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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