Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disr...

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Veröffentlicht in:	bioRxiv
Hauptverfasser:	Teng, Shaolei, Thomson, Pippa, Mccarthy, Shane, Kramer, Melissa, Muller, Stephanie, Lihm, Jayon, Morris, Stewart, Soares, Dinesh, Hennah, William, Harris, Sarah, Luiz Miguel Camargo, Malkov, Vladislav, Mcintosh, Andrew, Millar, J Kirsty, Blackwood, Douglas, Evans, Kathryn, Deary, Ian, Porteous, David, Mccombie, W Richard
Format:	Paper
Sprache:	Englisch
Veröffentlicht:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.10.2016 Cold Spring Harbor Laboratory
Ausgabe:	1.1
Schlagworte:	Bipolar disorder Cognitive ability Disc1 protein Genetics Mental disorders Neurodevelopmental disorders Neurosis Phenotypes Pleiotropy Schizophrenia
ISSN:	2692-8205, 2692-8205
Online-Zugang:	Volltext
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