Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome

Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 (N8) from activated Cullins. The structure of stable CSN-CRL can be used to understand this mechanism of regulation. Here we pre...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Faull, Sarah V, Lau, Andy, Martens, Chloe, Ahdash, Zainab, Yebenes, Hugo, Schmidt, Carla, Beuron, Fabienne, Cronin, Nora B, Morris, Edward P, Politis, Argyris
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 29.11.2018 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Biochemistry Cullin Electron microscopy Mass spectroscopy Ubiquitin-protein ligase
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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