Feedback Inhibition Underlies New Computational Functions of Cerebellar Interneurons

The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in th...

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Hlavní autoři: Halverson, Hunter E., Kim, Jinsook, Khilkevich, Andrei, Mauk, Michael D., Augustine, George J.
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Jazyk:angličtina
Vydáno: Cold Spring Harbor Laboratory 03.03.2022
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Neuroscience
ISSN:2692-8205
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Abstract The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 μm) and is based on convergence of 1-2 Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases at the same time that Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.
AbstractList The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 μm) and is based on convergence of 1-2 Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases at the same time that Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.
Author Kim, Jinsook
Augustine, George J.
Khilkevich, Andrei
Halverson, Hunter E.
Mauk, Michael D.
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  surname: Augustine
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References Halverson, Khilkevich, Mauk (2022.03.03.482855v1.32) 2015; 35
Witter, Rudolph, Pressler, Lahlaf, Regehr (2022.03.03.482855v1.5) 2016; 91
Pouzat, Hestrin (2022.03.03.482855v1.19) 1997; 17
Larramendi, Lemkey-Johnston (2022.03.03.482855v1.40) 1970; 138
ten Brinke, Boele, Spanke, Potters, Kornysheva, Wulff, Ijpelaar, Koekkoek, De Zeeuw (2022.03.03.482855v1.50) 2015; 13
Barski, Dethleffsen, Meyer (2022.03.03.482855v1.6) 2000; 28
Giovannucci, Badura, Deverett, Najafi, Pereira, Gao, Ozden, Kloth, Pnevmatikakis, De Zeeuw, Medina, Wang (2022.03.03.482855v1.30); 20
Orduz, Llano (2022.03.03.482855v1.12) 2007; 104
Mauk, Donegan (2022.03.03.482855v1.3) 1997; 4
Li, Hausknecht, Stone, Mauk (2022.03.03.482855v1.21) 2013; 47
Zhou (2022.03.03.482855v1.14) 2014; 3
Ito (2022.03.03.482855v1.33) 1986; 3
Medina, Garcia, Mauk (2022.03.03.482855v1.26) 2001; 21
Medina, Nores, Mauk (2022.03.03.482855v1.22) 2002; 416
Houck, Person (2022.03.03.482855v1.31) 2015; 523
Simpson, Hulscher, Sabel-goedknegt, Ruigrok (2022.03.03.482855v1.36) 2005; 148
Chan-Palay (2022.03.03.482855v1.38) 1971; 134
Altman (2022.03.03.482855v1.18) 1972; 145
Gao, Solages, Lena (2022.03.03.482855v1.37) 2012; 106
Medina, Mauk (2022.03.03.482855v1.20) 2000; 3
Mapelli, Pagani, Garrido, D’Angelo (2022.03.03.482855v1.34) 2015; 9
Heiney, Kim, Augustine, Medina (2022.03.03.482855v1.35) 2014; 34
Kim (2022.03.03.482855v1.17) 2014; 7
O’Donoghue, Bishop (2022.03.03.482855v1.41) 1990; 80
Khilkevich, Zambrano, Richards, Mauk (2022.03.03.482855v1.29) 2018; 7
Ohyama, Voicu, Kalmbach, Mauk (2022.03.03.482855v1.27) 2010; 30
Bloedel, Roberts (2022.03.03.482855v1.43) 1969; 32
Khilkevich, Canton-Josh, DeLord, Mauk (2022.03.03.482855v1.23) 2018; 4
Laine, Axelrad (2022.03.03.482855v1.10) 1994; 339
Song, Augustine (2022.03.03.482855v1.11) 2016; 36
Hong, Negrello, Junker, Smilgin, Their, De Schutter (2022.03.03.482855v1.47) 2016; 5
Medina, Garcia, Nores, Taylor, Mauk (2022.03.03.482855v1.25) 2000; 20
Guo (2022.03.03.482855v1.42) 2016; 91
Sudhakar, Torben-Nielsen, De Schutter (2022.03.03.482855v1.46) 2015; 11
Marr (2022.03.03.482855v1.2) 1969; 202
Lemkey-Johnston, Larramendi (2022.03.03.482855v1.44) 1968; 134
Eccles, Ito, Szentágothai (2022.03.03.482855v1.1) 1967
Madisen (2022.03.03.482855v1.7) 2012; 15
Asrican (2022.03.03.482855v1.8) 2013; 7
Kalmbach, Voicu, Ohyama, Mauk (2022.03.03.482855v1.28) 2011; 31
Thach (2022.03.03.482855v1.13) 1968; 31
Watt (2022.03.03.482855v1.9) 2009; 12
Medina, Mauk (2022.03.03.482855v1.24) 1999; 19
Jorntell, Bengtsson, Schonewille, De Zeeuw (2022.03.03.482855v1.49) 2010; 33
Hamori, Szentagothai (2022.03.03.482855v1.39) 1968; 5
Turecek, Jackman, Regehr (2022.03.03.482855v1.15) 2016; 17
O’donoghue, King, Bishop (2022.03.03.482855v1.4) 1989; 9
Wang (2022.03.03.482855v1.16) 2007; 104
Jorntell, Ekerot (2022.03.03.482855v1.48) 2002; 34
Satterlie (2022.03.03.482855v1.45) 1985; 229
References_xml – volume: 20
  start-page: 5516
  year: 2000
  end-page: 5525
  ident: 2022.03.03.482855v1.25
  article-title: Timing mechanisms in the cerebellum: Testing predictions of a large scale computer simulation
  publication-title: J Neurosci
– volume: 12
  start-page: 463
  year: 2009
  end-page: 473
  ident: 2022.03.03.482855v1.9
  article-title: Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity
  publication-title: Nat Neurosci
– volume: 17
  start-page: 9104
  year: 1997
  end-page: 9112
  ident: 2022.03.03.482855v1.19
  article-title: Developmental regulation of basket/stellate cell-->Purkinje cell synapses in the cerebellum
  publication-title: J Neurosci
– volume: 202
  start-page: 437
  year: 1969
  end-page: 470
  ident: 2022.03.03.482855v1.2
  article-title: A theory of cerebellar cortex
  publication-title: J Physiol
– volume: 134
  start-page: 200
  year: 1971
  end-page: 234
  ident: 2022.03.03.482855v1.38
  article-title: The recurrent collaterals of Purkinje cell axons: a correlated study of the rat’s cerebellar cortex with electron microscopy and the Golgi method
  publication-title: Z Anat Entwicklungsgesch
– volume: 5
  issue: e13810
  year: 2016
  ident: 2022.03.03.482855v1.47
  article-title: Multiplexed coding by cerebellar Purkinje neurons
  publication-title: Elife
– volume: 3
  issue: e02536
  year: 2014
  ident: 2022.03.03.482855v1.14
  article-title: Cerebellar modules operate at different frequencies
  publication-title: Elife
– volume: 7
  issue: 160
  year: 2013
  ident: 2022.03.03.482855v1.8
  article-title: Next-generation transgenic mice for optogenetic analysis of neural circuits
  publication-title: Front Neural Circuits
– volume: 148
  start-page: 329
  year: 2005
  end-page: 340
  ident: 2022.03.03.482855v1.36
  article-title: Between in and out: linking morphology and physiology of cerebellar cortical interneurons
  publication-title: Prog Brain Res
– year: 1967
  ident: 2022.03.03.482855v1.1
  article-title: The cerebellum as a neuronal machine (Springer- Verlag, Berlin
  publication-title: New York etc
– volume: 20
  start-page: 727
  end-page: 734
  ident: 2022.03.03.482855v1.30
  article-title: Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning
  publication-title: Nat Neurosci
– volume: 3
  start-page: 531
  year: 1986
  end-page: 539
  ident: 2022.03.03.482855v1.33
  article-title: Long-term depression as a memory process in the cerebellum
  publication-title: Neurosci Res
– volume: 30
  start-page: 16993
  issue: 50
  year: 2010
  end-page: 17003
  ident: 2022.03.03.482855v1.27
  article-title: A decrementing form of plasticity apparent in cerebellar learning
  publication-title: J Neurosci
– volume: 523
  start-page: 2254
  year: 2015
  end-page: 2271
  ident: 2022.03.03.482855v1.31
  article-title: Cerebellar premotor output neurons collateralize to innervate the cerebellar cortex
  publication-title: J Comp Neurol
– volume: 7
  issue: e37443
  year: 2018
  ident: 2022.03.03.482855v1.29
  article-title: Cerebellar implementation of movement sequences through feedback
  publication-title: Elife
– volume: 21
  start-page: 4081
  year: 2001
  end-page: 4089
  ident: 2022.03.03.482855v1.26
  article-title: A mechanism for savings in the cerebellum
  publication-title: J Neurosci
– volume: 9
  start-page: 2141
  year: 1989
  end-page: 2150
  ident: 2022.03.03.482855v1.4
  article-title: Physiological and anatomical studies of the interactions between Purkinje cells and basket cells in the cat’s cerebellar cortex: evidence for a unitary relationship
  publication-title: J Neurosci
– volume: 145
  start-page: 399
  year: 1972
  end-page: 463
  ident: 2022.03.03.482855v1.18
  article-title: Postnatal development of the cerebellar cortex in the rat
  publication-title: II. Phases in the maturation of Purkinje cells and of the molecular layer. J Comp Neurol
– volume: 4
  start-page: 1
  year: 2018
  end-page: 12
  ident: 2022.03.03.482855v1.23
  article-title: A cerebellar adaptation to uncertain inputs
  publication-title: Sci Adv
– volume: 339
  start-page: 159
  year: 1994
  end-page: 173
  ident: 2022.03.03.482855v1.10
  article-title: The candelabrum cell: a new interneuron in the cerebellar cortex
  publication-title: j Comp Neurol
– volume: 4
  start-page: 130
  year: 1997
  end-page: 158
  ident: 2022.03.03.482855v1.3
  article-title: A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum
  publication-title: Learn Mem
– volume: 3
  start-page: 1205
  year: 2000
  end-page: 1211
  ident: 2022.03.03.482855v1.20
  article-title: Computer simulation of cerebellar information processing
  publication-title: Nat Neurosci
– volume: 134
  start-page: 73
  year: 1968
  end-page: 112
  ident: 2022.03.03.482855v1.44
  article-title: Types and distribution of synapses upon basket and stellate cells of the mouse cerebellum: an electron microscopic study
  publication-title: J Comp Neurol
– volume: 17
  start-page: 3256
  year: 2016
  end-page: 3268
  ident: 2022.03.03.482855v1.15
  article-title: Synaptic specializations support frequency- independent Purkinje cell output from the cerebellar cortex
  publication-title: Cell Rep
– volume: 31
  start-page: 2025
  issue: 6
  year: 2011
  end-page: 2034
  ident: 2022.03.03.482855v1.28
  article-title: A subtraction mechanism of temporal coding in cerebellum
  publication-title: J Neurosci
– volume: 229
  start-page: 402
  year: 1985
  end-page: 404
  ident: 2022.03.03.482855v1.45
  article-title: Reciprocal inhibition and postinhibitory rebound produce reverberation in a locomotor pattern generator
  publication-title: Science
– volume: 80
  start-page: 63
  year: 1990
  end-page: 71
  ident: 2022.03.03.482855v1.41
  article-title: A quantitative analysis of the distribution of Purkinje cell axonal collaterals in different zones of the cat’s cerebellum: an intracellular HRP study
  publication-title: Exp Brain Res
– volume: 5
  start-page: 118
  year: 1968
  end-page: 128
  ident: 2022.03.03.482855v1.39
  article-title: Identification of synapses formed in the cerebellar cortex by Purkinje axon collaterals: an electron microscope study
  publication-title: Exp Brain Res
– volume: 104
  start-page: 17831
  year: 2007
  end-page: 17836
  ident: 2022.03.03.482855v1.12
  article-title: Recurrent axon collaterals underlie facilitating synapses between cerebellar Purkinje cells
  publication-title: Proc Natl Acad Sci U S A
– volume: 36
  start-page: 6742
  year: 2016
  end-page: 6757
  ident: 2022.03.03.482855v1.11
  article-title: Synapsin isoforms regulating gaba release from hippocampal interneurons
  publication-title: J Neurosci
– volume: 34
  start-page: 2321
  year: 2014
  end-page: 2330
  ident: 2022.03.03.482855v1.35
  article-title: Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity
  publication-title: J Neurosci
– volume: 19
  start-page: 7140
  year: 1999
  end-page: 7151
  ident: 2022.03.03.482855v1.24
  article-title: Simulations of cerebellar motor learning: Computational analysis of plasticity at the mossy fiber to deep nucleus synapses
  publication-title: J Neurosci
– volume: 91
  start-page: 312
  year: 2016
  end-page: 319
  ident: 2022.03.03.482855v1.5
  article-title: Purkinje cell collaterals enable output signals from the cerebellar cortex to feed back to Purkinje cells and interneurons
  publication-title: Neuron
– volume: 7
  start-page: 1601
  year: 2014
  end-page: 1613
  ident: 2022.03.03.482855v1.17
  article-title: Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses
  publication-title: Cell Rep
– volume: 47
  start-page: 95
  year: 2013
  end-page: 102
  ident: 2022.03.03.482855v1.21
  article-title: Using a million cell simulation of the cerebellum: network scaling and task generality
  publication-title: Neural Netw
– volume: 35
  start-page: 7813
  year: 2015
  end-page: 7832
  ident: 2022.03.03.482855v1.32
  article-title: Relating cerebellar Purkinje cell activity to the timing and amplitude of conditioned eyelid responses
  publication-title: J Neurosci
– volume: 9
  issue: 169
  year: 2015
  ident: 2022.03.03.482855v1.34
  article-title: Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit
  publication-title: Front Cell Neurosci
– volume: 33
  start-page: 524
  year: 2010
  end-page: 532
  ident: 2022.03.03.482855v1.49
  article-title: Cerebellar molecular layer interneurons - computational properties and roles in learning
  publication-title: Trends Neurosci
– volume: 104
  start-page: 8143
  year: 2007
  end-page: 8148
  ident: 2022.03.03.482855v1.16
  article-title: High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice
  publication-title: Proc Natl Acad Sci U S A
– volume: 11
  issue: e1004641
  year: 2015
  ident: 2022.03.03.482855v1.46
  article-title: Cerebellar nuclear neruons use time and rate coding to transmit Purkinje neuron pauses
  publication-title: PloS Comput Biol
– volume: 34
  start-page: 797
  year: 2002
  end-page: 806
  ident: 2022.03.03.482855v1.48
  article-title: Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons
  publication-title: Neuron
– volume: 13
  start-page: 1977
  year: 2015
  end-page: 1988
  ident: 2022.03.03.482855v1.50
  article-title: Evolving models of pavlovian conditioning: Cerebellar cortical dynamics in awake behaving mice
  publication-title: Cell Rep
– volume: 138
  start-page: 451
  year: 1970
  end-page: 459
  ident: 2022.03.03.482855v1.40
  article-title: The distribution of recurrent Purkinje collateral synapses in the mouse cerebellar cortex: an electron microscopic study
  publication-title: J Comp Neurol
– volume: 31
  start-page: 785
  year: 1968
  end-page: 797
  ident: 2022.03.03.482855v1.13
  article-title: Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey
  publication-title: J Neurophysiol
– volume: 106
  start-page: 128
  year: 2012
  end-page: 136
  ident: 2022.03.03.482855v1.37
  article-title: Tetrode recordings in the cerebellar cortex
  publication-title: J Physiol Paris
– volume: 32
  start-page: 75
  year: 1969
  end-page: 84
  ident: 2022.03.03.482855v1.43
  article-title: Functional relationship among neurons of the cerebellar cortex in the absence of anesthesia
  publication-title: J Neurophysiol
– volume: 28
  start-page: 93
  year: 2000
  end-page: 98
  ident: 2022.03.03.482855v1.6
  article-title: Cre recombinase expression in cerebellar Purkinje cells
  publication-title: genesis
– volume: 416
  start-page: 330
  year: 2002
  end-page: 333
  ident: 2022.03.03.482855v1.22
  article-title: Inhibition of climbing fibers is a signal for the extinction of conditioned eyelid responses
  publication-title: Nature
– volume: 15
  start-page: 793
  year: 2012
  end-page: 802
  ident: 2022.03.03.482855v1.7
  article-title: A toolbox of cre-dependent optogenetic transgenic mice for light- induced activation and silencing
  publication-title: Nat Neurosci
– volume: 91
  start-page: 1330
  year: 2016
  end-page: 1341
  ident: 2022.03.03.482855v1.42
  article-title: Purkinje cells directly inhibit granule cells in specialized regions of the cerebellar cortex
  publication-title: Neuron
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Snippet The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics,...
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SubjectTerms Neuroscience
Title Feedback Inhibition Underlies New Computational Functions of Cerebellar Interneurons
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